3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide

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Chemical Name:3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide
CAS No.:1376335-41-9
Molecular Formula:C₂₀H₂₁ClF₄N₄O₂
Molecular Weight:460.859
Hs Code.:

Synonyms:3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide

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Chemical Property of 3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide

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Technology Process of 3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide

There total 9 articles about 3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.8%

: 41463-83-6
3,3,3-trifluoropropanoyl chloride

: 1376335-40-8
[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazine

: 1376335-41-9
3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide

Guidance literature:: 3,3,3-trifluoropropanoyl chloride; [3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazine; With triethylamine; In dichloromethane; at 0 - 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 255893-55-1
4-(5-fluoro-2-methoxy-phenyl)-piperidine

: 1376335-41-9
3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 110 °C

2: hydrazine / tetrahydrofuran / 0.25 h / 160 °C / Microwave irradiation

3: triethylamine / dichloromethane / 0 - 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm300912k

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1376335-41-9
3,3,3-trifluoro-propionic acid N'-[3'-chloro-4-(5-fluoro-2-methoxy-phenyl)-3,4,5,6,tetrahydro-2H-[1,4']bipyridinyl-2'-yl]-hydrazide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.17 h / 150 °C / Microwave irradiation

2: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 80 °C

3: hydrogenchloride / methanol; isopropyl alcohol / 1.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 110 °C

5: hydrazine / tetrahydrofuran / 0.25 h / 160 °C / Microwave irradiation

6: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm300912k