tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate
CAS No.:1271523-25-1
Molecular Formula:C₂₈H₂₇Cl₂N₃O₄
Molecular Weight:540.446
Hs Code.:

Synonyms:tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Suppliers and Price of tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

There total 8 articles about tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73852-17-2
2,6-dichlorophenylboronic acid

: 376584-36-0
[5-chloro-1-(4-methoxy-benzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

: 1271523-25-1
tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Guidance literature:: With potassium carbonate; silver carbonate; In tetrahydrofuran; for 1h; Reflux;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1271523-25-1
tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / dichloromethane / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: bis(trichloromethyl) carbonate / tetrahydrofuran / 20 °C

3.1: acetic acid / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / Reflux

5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 0.75 h / -78 °C / Inert atmosphere

5.3: -78 - 20 °C / Inert atmosphere

6.1: hydrogen / platinum(IV) oxide / 1,4-dioxane

7.1: potassium carbonate; silver carbonate / tetrahydrofuran / 1 h / Reflux

With bis(trichloromethyl) carbonate; potassium tert-butylate; hydrogen; potassium carbonate; acetic acid; N,N-dimethyl-aniline; silver carbonate; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; toluene;

Reference yield:

: 16512-74-6
1-(4-methoxybenzyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

: 1271523-25-1
tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / Reflux

2.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / Reflux

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.75 h / -78 °C / Inert atmosphere

3.3: -78 - 20 °C / Inert atmosphere

4.1: hydrogen / platinum(IV) oxide / 1,4-dioxane

5.1: potassium carbonate; silver carbonate / tetrahydrofuran / 1 h / Reflux

With potassium tert-butylate; hydrogen; potassium carbonate; N,N-dimethyl-aniline; silver carbonate; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; acetic acid; toluene;