(+)-N-[(1S,2S)-4,4,4-trichloro-2-methyl-3-oxo-1-phenylbutan-1-yl]-2-thiophenesulfonamide

Base Information

Chemical Name:(+)-N-[(1S,2S)-4,4,4-trichloro-2-methyl-3-oxo-1-phenylbutan-1-yl]-2-thiophenesulfonamide
CAS No.:949007-21-0
Molecular Formula:C₁₅H₁₄Cl₃NO₃S₂
Molecular Weight:426.772
Hs Code.:

Synonyms:(+)-N-[(1S,2S)-4,4,4-trichloro-2-methyl-3-oxo-1-phenylbutan-1-yl]-2-thiophenesulfonamide

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Chemical Property of (+)-N-[(1S,2S)-4,4,4-trichloro-2-methyl-3-oxo-1-phenylbutan-1-yl]-2-thiophenesulfonamide

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Technology Process of (+)-N-[(1S,2S)-4,4,4-trichloro-2-methyl-3-oxo-1-phenylbutan-1-yl]-2-thiophenesulfonamide

There total 2 articles about (+)-N-[(1S,2S)-4,4,4-trichloro-2-methyl-3-oxo-1-phenylbutan-1-yl]-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: (E)-N-benzylidenethiophene-2-sulfonamide

: 815-01-0
ethyl trichloromethyl ketone

: 949007-21-0
(+)-N-[(1S,2S)-4,4,4-trichloro-2-methyl-3-oxo-1-phenylbutan-1-yl]-2-thiophenesulfonamide

: anti-N-[4,4,4-trichloro-2-methyl-3-oxo-1-phenylbutan-1-yl]-2-thiophenesulfonamide

Guidance literature:: ethyl trichloromethyl ketone; With La(4-MeO-C₆H₄-O)3; Li(4-MeO-C₆H₄-O); (S,S)-i-Pr-pybox; 3 A molecular sieve; In tetrahydrofuran; at -40 ℃; for 0.0833333h;

(E)-N-benzylidenethiophene-2-sulfonamide; In tetrahydrofuran; toluene; at -40 ℃; for 16h; Further stages.;
DOI:10.1021/ja073285p

Reference yield:

: 100-52-7
benzaldehyde

: 949007-21-0
(+)-N-[(1S,2S)-4,4,4-trichloro-2-methyl-3-oxo-1-phenylbutan-1-yl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / Amberlyst 15; molecular sieves 4 Angstroem / toluene / 11 h / Heating

2.1: La(4-MeO-C₆H₄-O)3; Li(4-MeO-C₆H₄-O); (S,S)-i-Pr-pybox / molecular sieves 3 Angstroem / tetrahydrofuran / 0.08 h / -40 °C

2.2: 98 percent / tetrahydrofuran; toluene / 16 h / -40 °C

With Amberlyst 15; 4 A molecular sieve; 3 A molecular sieve; In tetrahydrofuran; toluene;
DOI:10.1021/ja073285p