(-)-methyl (2S,3S)-2-methyl-3-phenyl-3-[(2-thiophenesulfonyl)amino]propionate

Base Information

Chemical Name:(-)-methyl (2S,3S)-2-methyl-3-phenyl-3-[(2-thiophenesulfonyl)amino]propionate
CAS No.:949007-12-9
Molecular Formula:C₁₅H₁₇NO₄S₂
Molecular Weight:339.436
Hs Code.:

Synonyms:(-)-methyl (2S,3S)-2-methyl-3-phenyl-3-[(2-thiophenesulfonyl)amino]propionate

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Chemical Property of (-)-methyl (2S,3S)-2-methyl-3-phenyl-3-[(2-thiophenesulfonyl)amino]propionate

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Technology Process of (-)-methyl (2S,3S)-2-methyl-3-phenyl-3-[(2-thiophenesulfonyl)amino]propionate

There total 3 articles about (-)-methyl (2S,3S)-2-methyl-3-phenyl-3-[(2-thiophenesulfonyl)amino]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 949007-21-0
(+)-N-[(1S,2S)-4,4,4-trichloro-2-methyl-3-oxo-1-phenylbutan-1-yl]-2-thiophenesulfonamide

: 949007-12-9
(-)-methyl (2S,3S)-2-methyl-3-phenyl-3-[(2-thiophenesulfonyl)amino]propionate

Guidance literature:: With sodium methylate; at 0 ℃; for 0.333333h;
DOI:10.1021/ja073285p

Reference yield:

: (E)-N-benzylidenethiophene-2-sulfonamide

: 949007-12-9
(-)-methyl (2S,3S)-2-methyl-3-phenyl-3-[(2-thiophenesulfonyl)amino]propionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: La(4-MeO-C₆H₄-O)3; Li(4-MeO-C₆H₄-O); (S,S)-i-Pr-pybox / molecular sieves 3 Angstroem / tetrahydrofuran / 0.08 h / -40 °C

1.2: 98 percent / tetrahydrofuran; toluene / 16 h / -40 °C

2.1: 100 percent / NaOMe / 0.33 h / 0 °C

With sodium methylate; 3 A molecular sieve; In tetrahydrofuran;
DOI:10.1021/ja073285p

Reference yield:

: 100-52-7
benzaldehyde

: 949007-12-9
(-)-methyl (2S,3S)-2-methyl-3-phenyl-3-[(2-thiophenesulfonyl)amino]propionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / Amberlyst 15; molecular sieves 4 Angstroem / toluene / 11 h / Heating

2.1: La(4-MeO-C₆H₄-O)3; Li(4-MeO-C₆H₄-O); (S,S)-i-Pr-pybox / molecular sieves 3 Angstroem / tetrahydrofuran / 0.08 h / -40 °C

2.2: 98 percent / tetrahydrofuran; toluene / 16 h / -40 °C

3.1: 100 percent / NaOMe / 0.33 h / 0 °C

With Amberlyst 15; 4 A molecular sieve; sodium methylate; 3 A molecular sieve; In tetrahydrofuran; toluene;
DOI:10.1021/ja073285p