2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline

Base Information

• Chemical Name: 2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline
• CAS No.: 87226-64-0
• Molecular Formula: C₂₂H₂₉NO₃
• Molecular Weight: 355.477
• Mol file: 87226-64-0.mol

Synonyms:2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline

Chemical Property of 2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline

There total 6 articles about 2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline (53416-46-9) → 2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline (87226-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / 1.) n-BuLi / diethyl ether / 1.) -15 deg C, 4 h, 2.) room temperature, 3 h

2: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

3: 1.) HCOOH / 1.) room temperature, 10 h, 2.) THF, room temperature, 1 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; formic acid; In diethyl ether;

DOI:10.1021/ja00360a027

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) → 2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline (87226-64-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 2.) SO₂Cl, 3.) NaOH / 1.) CH₂Cl₂, 0 deg C to room temperature, 10 h, 2.) room temperature, 3 h, 3.) 0.5 h

2: 92 percent / 1.) n-BuLi / diethyl ether / 1.) -15 deg C, 4 h, 2.) room temperature, 3 h

3: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

4: 1.) HCOOH / 1.) room temperature, 10 h, 2.) THF, room temperature, 1 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; formic acid; sulfuryl dichloride; In diethyl ether;

DOI:10.1021/ja00360a027

Reference yield:

2-(2-methyl-4-methoxyphenyl)4,4-dimethyl-2-oxazoline (75817-44-6) → 2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline (87226-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

2: 1.) HCOOH / 1.) room temperature, 10 h, 2.) THF, room temperature, 1 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; formic acid;

DOI:10.1021/ja00360a027

upstream raw materials:

isopropenylmagnesium bromide

7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline

2-(2-methyl-4-methoxyphenyl)4,4-dimethyl-2-oxazoline

Downstream raw materials:

1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene

1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone

[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenylethynyl]-trimethyl-silane