6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide

Base Information

Chemical Name:6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide
CAS No.:1415756-03-4
Molecular Formula:C₁₈H₁₆F₂N₄O₂
Molecular Weight:358.347
Hs Code.:

Synonyms:6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide

Suppliers and Price of 6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide

There total 10 articles about 6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1415757-40-2
(R)-2-{3-fluoro-4-[(6-fluoro-1H-indazole-3-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester

: 1415756-03-4
6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide

Guidance literature:: (R)-2-{3-fluoro-4-[(6-fluoro-1H-indazole-3-carbonyl)-amino]-phenyl}-morpholine-4-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In water; acetonitrile; at 80 ℃; for 5h;

With sodium hydroxide; In water; acetonitrile; at 20 ℃;

Reference yield:

: 695188-21-7
4-bromo-3-fluorobenzoyl chloride

: 1415756-03-4
6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide

Guidance literature:: Multi-step reaction with 10 steps

1.1: diethyl ether; acetonitrile; tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 0.5 h / 0 - 20 °C

2.1: ethanol; sodium tetrahydroborate / 1.08 h / 5 - 20 °C

2.2: 20 - 40 °C

3.1: tetrahydrofuran / 20 °C

4.1: dichloromethane / 20 °C

5.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

5.2: 1 h / 0 - 20 °C

6.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 1 h / 100 °C / Inert atmosphere

7.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / 60 °C / Inert atmosphere

8.1: Chiralpak AD / isopropyl alcohol; n-heptane / 13501.4 Torr / Resolution of racemate

9.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / N,N-dimethyl-formamide; tetrahydrofuran / 42 h / 50 - 60 °C

10.1: trifluoroacetic acid / acetonitrile; water / 5 h / 80 °C

10.2: 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; ethanol; ammonium formate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; methanol; diethyl ether; n-heptane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1260857-14-4
2-chloro-1-(4-bromo-3-fluorophenyl)-ethanone

: 1415756-03-4
6-fluoro-1H-indazole-3-carboxylic acid ((R)-2-fluoro-4-morpholin-2-yl-phenyl)amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: ethanol; sodium tetrahydroborate / 1.08 h / 5 - 20 °C

1.2: 20 - 40 °C

2.1: tetrahydrofuran / 20 °C

3.1: dichloromethane / 20 °C

4.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

4.2: 1 h / 0 - 20 °C

5.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 1 h / 100 °C / Inert atmosphere

6.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / 60 °C / Inert atmosphere

7.1: Chiralpak AD / isopropyl alcohol; n-heptane / 13501.4 Torr / Resolution of racemate

8.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / N,N-dimethyl-formamide; tetrahydrofuran / 42 h / 50 - 60 °C

9.1: trifluoroacetic acid / acetonitrile; water / 5 h / 80 °C

9.2: 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; ethanol; ammonium formate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; methanol; n-heptane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;