Ethanethiol, 2-(methylamino)-, hydrochloride

Base Information

• Chemical Name: Ethanethiol, 2-(methylamino)-, hydrochloride
• CAS No.: 33744-33-1
• Molecular Formula: C3H10ClNS
• Molecular Weight: 127.638
• European Community (EC) Number: 608-902-1
• DSSTox Substance ID: DTXSID40187420
• Mol file: 33744-33-1.mol

Synonyms:33744-33-1;Ethanethiol, 2-(methylamino)-, hydrochloride;2-(Methylamino)ethanethiol hydrochloride;M-2PA;2-(methylamino)ethane-1-thiol hydrochloride;2-(methylamino)ethanethiol;hydrochloride;SCHEMBL296081;DTXSID40187420;2-methylaminoethanethiol hydrochloride;AT25552;LS-66012;2-(METHYLAMINO)ETHANE-1-THIOL HCL;2-(methylamino)ethane-1-thiolhydrochloride;EN300-200540

Chemical Property of Ethanethiol, 2-(methylamino)-, hydrochloride

Chemical Property:

• Vapor Pressure: 41.3mmHg at 25°C
• Boiling Point: 97.7°C at 760 mmHg
• Flash Point: 12.9°C
• PSA: 50.83000
• LogP: 1.32850
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 127.0222482
• Heavy Atom Count: 6
• Complexity: 16.4

Purity/Quality:

99% ^*data from raw suppliers

2-(methylamino)ethane-1-thiolhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCCS.Cl

Technology Process of Ethanethiol, 2-(methylamino)-, hydrochloride

There total 5 articles about Ethanethiol, 2-(methylamino)-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(N-tert-butoxycarbonyl-N-methylamino)ethanthiol (134464-53-2) → β-methylaminoethanethiol hydrochloride (33744-33-1)

Guidance literature:

With hydrogenchloride; In methanol; at 0 ℃; for 0.5h; Inert atmosphere; Cooling with ice;

DOI:10.1002/anie.201106432

Reference yield: 79.0%

N-methyl-2-chloroethylamine hydrochloride (4535-90-4) → β-methylaminoethanethiol hydrochloride (33744-33-1)

Guidance literature:

N-methyl-2-chloroethylamine hydrochloride; With sodium thiosulfate; In water; for 26h; Heating;

With hydrogenchloride; at 85 ℃; for 3h; Further stages.;

DOI:10.1021/ja800800p

Reference yield: 63.0%

thiazolidine hydrochloride (14446-47-0) → β-methylaminoethanethiol hydrochloride (33744-33-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

DOI:10.1016/j.bbrc.2010.11.052

upstream raw materials:

1,3-thiazolidine

N-methyl-2-chloroethylamine hydrochloride

N-methyl-2-[(Z)-(methylsulfonyl)methylidene]thiazolidine

thiazolidine hydrochloride

Downstream raw materials:

[2-(2,6-Dinitro-phenylsulfanyl)-ethyl]-methyl-amine; hydrochloride

1-(β-methylaminoethylthio)-2,4-dinitrobenzene hydrochloride

methyl-[2-(2,4,6-trinitro-phenylsulfanyl)-ethyl]-amine

(Z)-4-(1-(6-(2-(methylamino)ethylthio)pyridin-3-yl)-2-phenylbut-1-enyl)phenol