1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone

Base Information

Chemical Name:1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone
CAS No.:174258-50-5
Molecular Formula:C₂₀H₁₆F₃NO₃
Molecular Weight:375.347
Hs Code.:

Synonyms:1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone

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Chemical Property of 1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone

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Technology Process of 1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone

There total 3 articles about 1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 121-71-1
3-Hydroxyacetophenone

: 174258-39-0
4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

: 174258-50-5
1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 10h;
DOI:10.1021/jm990476x

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 174258-50-5
1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

With hydrogenchloride; potassium carbonate; trichlorophosphate; In chloroform; ethyl acetate; N,N-dimethyl-formamide; 1: Condensation / 2: Chlorination / 3: Alkylation;
DOI:10.1021/jm990476x

Reference yield:

: 475480-98-9
4,5-dimethyl-2-(4-trifluoromethylphenyl)-oxazole 3-oxide

: 174258-50-5
1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

2: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

With potassium carbonate; trichlorophosphate; In chloroform; N,N-dimethyl-formamide; 1: Chlorination / 2: Alkylation;
DOI:10.1021/jm990476x