ethyl (E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenoate

Base Information

Chemical Name:ethyl (E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenoate
CAS No.:174258-51-6
Molecular Formula:C₂₄H₂₂F₃NO₄
Molecular Weight:445.438
Hs Code.:

Synonyms:ethyl (E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenoate

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Chemical Property of ethyl (E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenoate

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Technology Process of ethyl (E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenoate

There total 4 articles about ethyl (E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 174258-50-5
1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone

: 174258-51-6
ethyl (E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenoate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In toluene; for 1h;

1-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-1-ethanone; In tetrahydrofuran; toluene; for 48h; Further stages.;
DOI:10.1021/jm990476x

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 174258-51-6
ethyl (E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

4.1: NaH / toluene / 1 h

4.2: 81 percent / toluene; tetrahydrofuran / 48 h

With hydrogenchloride; sodium hydride; potassium carbonate; trichlorophosphate; In chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation;
DOI:10.1021/jm990476x

Reference yield:

: 174258-39-0
4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

: 174258-51-6
ethyl (E)-3-[3-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methoxy)phenyl]-2-butenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

2.1: NaH / toluene / 1 h

2.2: 81 percent / toluene; tetrahydrofuran / 48 h

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Condensation;
DOI:10.1021/jm990476x