N-[3-chloro-4-(α-hydroxybenzyl)-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide

Base Information

Chemical Name:N-[3-chloro-4-(α-hydroxybenzyl)-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide
CAS No.:749875-31-8
Molecular Formula:C₁₈H₁₈ClF₃N₂O₂
Molecular Weight:386.801
Hs Code.:

Synonyms:N-[3-chloro-4-(α-hydroxybenzyl)-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide

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Chemical Property of N-[3-chloro-4-(α-hydroxybenzyl)-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide

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Technology Process of N-[3-chloro-4-(α-hydroxybenzyl)-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide

There total 3 articles about N-[3-chloro-4-(α-hydroxybenzyl)-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 100-52-7
benzaldehyde

: 430454-70-9
N-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide

: 749875-31-8
N-[3-chloro-4-(α-hydroxybenzyl)-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide

Guidance literature:: N-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

benzaldehyde; In tetrahydrofuran; hexane;
DOI:10.1055/s-2004-829111

Reference yield:

: 3282-30-2
pivaloyl chloride

: 749875-31-8
N-[3-chloro-4-(α-hydroxybenzyl)-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 43 percent / pyridine / CH₂Cl₂ / 120 h / Heating

2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -75 °C

2.2: 58 percent / tetrahydrofuran; hexane

With pyridine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-2004-829111

Reference yield:

: 79456-26-1
2-amino-3-chloro-5-(trifluoromethyl)pyridine

: 749875-31-8
N-[3-chloro-4-(α-hydroxybenzyl)-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 43 percent / pyridine / CH₂Cl₂ / 120 h / Heating

2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -75 °C

2.2: 58 percent / tetrahydrofuran; hexane

With pyridine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-2004-829111