4-(bis(4-methoxybenzyl)amino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)pyrido[4,3-d]pyrimidine-8-carboxamide

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Chemical Name:4-(bis(4-methoxybenzyl)amino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)pyrido[4,3-d]pyrimidine-8-carboxamide
CAS No.:1269421-69-3
Molecular Formula:C₃₃H₃₂F₂N₆O₅S
Molecular Weight:662.717
Hs Code.:

Synonyms:4-(bis(4-methoxybenzyl)amino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)pyrido[4,3-d]pyrimidine-8-carboxamide

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Chemical Property of 4-(bis(4-methoxybenzyl)amino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)pyrido[4,3-d]pyrimidine-8-carboxamide

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Technology Process of 4-(bis(4-methoxybenzyl)amino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)pyrido[4,3-d]pyrimidine-8-carboxamide

There total 11 articles about 4-(bis(4-methoxybenzyl)amino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)pyrido[4,3-d]pyrimidine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1103234-57-6
N-(3-amino-2,4-difluorophenyl)propane-1-sulfonamide

: 1269421-60-4
4-(bis(4-methoxybenzyl)amino)pyrido[4,3-d]pyrimidine-8-carboxylic acid

: 1269421-69-3
4-(bis(4-methoxybenzyl)amino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)pyrido[4,3-d]pyrimidine-8-carboxamide

Guidance literature:: 4-(bis(4-methoxybenzyl)amino)pyrido[4,3-d]pyrimidine-8-carboxylic acid; With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃; for 0.416667h;

N-(3-amino-2,4-difluorophenyl)propane-1-sulfonamide; In chloroform; at 60 ℃; for 0.75h;

Reference yield:

: 52834-08-9
4-amino-5-bromonicotinic acid

: 1269421-69-3
4-(bis(4-methoxybenzyl)amino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)pyrido[4,3-d]pyrimidine-8-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4 h / 180 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / 5 h / Reflux

3.1: tetrahydrofuran / 0.25 h / 90 °C / Microwave irradiation

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / Reflux

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

6.1: oxalyl dichloride / dichloromethane / 0.42 h / 0 - 20 °C

6.2: 0.75 h / 60 °C

With thionyl chloride; oxalyl dichloride; lithium hydroxide monohydrate; water; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 83141-10-0
2,6-difluoro-3-nitrobenzoic acid

: 1269421-69-3
4-(bis(4-methoxybenzyl)amino)-N-(2,6-difluoro-3-(propylsulfonamido)phenyl)pyrido[4,3-d]pyrimidine-8-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 2 h / Cooling with water bath

2.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with water bath

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C

5.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C

5.2: 15 h / 80 °C

6.1: oxalyl dichloride / dichloromethane / 0.42 h / 0 - 20 °C

6.2: 0.75 h / 60 °C

With methanol; oxalyl dichloride; diphenyl phosphoryl azide; water; hydrogen; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; 5.2: Curtius Rearrangement;