((3R,4S)-1-Benzyl-2-oxo-3-vinyl-piperidin-4-yl)-acetic acid methyl ester

Base Information

Chemical Name:((3R,4S)-1-Benzyl-2-oxo-3-vinyl-piperidin-4-yl)-acetic acid methyl ester
CAS No.:134261-56-6
Molecular Formula:C₁₇H₂₁NO₃
Molecular Weight:287.359
Hs Code.:

Synonyms:((3R,4S)-1-Benzyl-2-oxo-3-vinyl-piperidin-4-yl)-acetic acid methyl ester

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Chemical Property of ((3R,4S)-1-Benzyl-2-oxo-3-vinyl-piperidin-4-yl)-acetic acid methyl ester

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Technology Process of ((3R,4S)-1-Benzyl-2-oxo-3-vinyl-piperidin-4-yl)-acetic acid methyl ester

There total 8 articles about ((3R,4S)-1-Benzyl-2-oxo-3-vinyl-piperidin-4-yl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 67-56-1
methanol

: 134261-55-5
(4aR,9S,9aS)-2-Benzyl-9-trimethylsilanyl-hexahydro-7-oxa-2-aza-benzocycloheptene-1,6-dione

: 134261-56-6
((3R,4S)-1-Benzyl-2-oxo-3-vinyl-piperidin-4-yl)-acetic acid methyl ester

Guidance literature:: With hydrogenchloride; for 24h; Ambient temperature;
DOI:10.1021/jo00015a036

Reference yield:

: 134261-49-7
N-benzyl-2-(1,3-dioxolan-2-yl)ethanamine

: 134261-56-6
((3R,4S)-1-Benzyl-2-oxo-3-vinyl-piperidin-4-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1) Et₃N / 1) CH₂Cl₂, 0 deg C, 5 min, 2) CH₂Cl₂, warm to r.t.

2: 30percent HCl / tetrahydrofuran / 42 h / Ambient temperature

3: 64 percent / tetrahydrofuran / 14 h / Heating

4: 1) Et₃N / 1) CH₂Cl₂, r.t., 5 min, 2) CH₂Cl₂, 5 min

5: 87 percent / KF*2H₂O / methanol / 2 h / Heating

6: 86 percent / m-CPBA, aq.Na₂HPO₄ / CH₂Cl₂ / 39 h / Ambient temperature

7: 71 percent / conc.HCl / 24 h / Ambient temperature

With hydrogenchloride; potassium fluoride; disodium hydrogenphosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00015a036

Reference yield:

: 134261-59-9
(E)-N-Benzyl-N-(3-oxo-propyl)-3-trimethylsilanyl-acrylamide

: 134261-56-6
((3R,4S)-1-Benzyl-2-oxo-3-vinyl-piperidin-4-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / tetrahydrofuran / 14 h / Heating

2: 1) Et₃N / 1) CH₂Cl₂, r.t., 5 min, 2) CH₂Cl₂, 5 min

3: 87 percent / KF*2H₂O / methanol / 2 h / Heating

4: 86 percent / m-CPBA, aq.Na₂HPO₄ / CH₂Cl₂ / 39 h / Ambient temperature

5: 71 percent / conc.HCl / 24 h / Ambient temperature

With hydrogenchloride; potassium fluoride; disodium hydrogenphosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00015a036