5-amino-1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 5-amino-1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile
• CAS No.: 111510-09-9
• Molecular Formula: C₁₆H₁₁ClN₄
• Molecular Weight: 294.743
• Mol file: 111510-09-9.mol

Synonyms:5-amino-1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile

Chemical Property of 5-amino-1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-amino-1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile

There total 10 articles about 5-amino-1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chlorobenzaldehyde (104-88-1) + phenylhydrazine (100-63-0) + malononitrile (109-77-3) → 5-amino-1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile (111510-09-9)

Guidance literature:

With potassium phtalimide; In ethanol; water; at 50 ℃; for 3h; Green chemistry;

DOI:10.3987/COM-16-13623

Reference yield: 92.0%

phenylhydrazine hydrochloride (59-88-1) + 4-chlorobenzaldehyde (104-88-1) + malononitrile (109-77-3) → 5-amino-1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile (111510-09-9)

Guidance literature:

With sodium tosylate; In water; at 20 ℃; Green chemistry;

DOI:10.1002/jhet.4077

Reference yield: 88.0%

malononitrile (109-77-3) + N-phenyl-p-chlorobenzohydrazonoyl chloride (36590-52-0) → 5-amino-1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile (111510-09-9)

Guidance literature:

malononitrile; With sodium ethanolate; In ethanol; for 0.166667h;

N-phenyl-p-chlorobenzohydrazonoyl chloride; In ethanol; at 20 ℃;

DOI:10.1002/jhet.3835

upstream raw materials:

3-(4-Chlorophenyl)-2-cyano-3-methylthioacrylonitrile

phenylhydrazine

methyl 4-chlorobenzenecarbodithioate

2-((4-chlorophenyl)(methoxy)methylene)malononitrile

Downstream raw materials:

4-Amino-3-(4-chlorophenyl)-1-phenylpyrazolo<3,4-d>pyrimidine