(S)-3-(4-Methoxy-3-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester

Base Information

Chemical Name:(S)-3-(4-Methoxy-3-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester
CAS No.:216502-63-5
Molecular Formula:C₁₆H₁₉F₃N₂O₆
Molecular Weight:392.332
Hs Code.:

Synonyms:(S)-3-(4-Methoxy-3-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(4-Methoxy-3-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester

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Technology Process of (S)-3-(4-Methoxy-3-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester

There total 5 articles about (S)-3-(4-Methoxy-3-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 216502-61-3
(S)-3-(4-Hydroxy-3-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester

: 74-88-4
methyl iodide

: 216502-63-5
(S)-3-(4-Methoxy-3-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In acetonitrile; for 48h; Heating;
DOI:10.1016/S0968-0896(98)00083-2

Reference yield:

: 16874-12-7,87553-74-0
Tyr(tBu)

: 216502-63-5
(S)-3-(4-Methoxy-3-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / CH₂Cl₂ / 2 h / 20 °C

2: 95 percent / HNO₃; HOAc / 1 h / 16 °C

3: DPPE; DIAD / 20 °C

With di-isopropyl azodicarboxylate; nitric acid; acetic acid; 1,2-bis-(diphenylphosphino)ethane; In dichloromethane;
DOI:10.1016/S0040-4039(01)02349-8