2-(1-acetylpiperidin-4-yloxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide

Base Information

Chemical Name:2-(1-acetylpiperidin-4-yloxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
CAS No.:1620390-68-2
Molecular Formula:C₂₀H₁₉Cl₂N₃O₅
Molecular Weight:452.294
Hs Code.:

Synonyms:2-(1-acetylpiperidin-4-yloxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide

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Chemical Property of 2-(1-acetylpiperidin-4-yloxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide

Chemical Property:

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Technology Process of 2-(1-acetylpiperidin-4-yloxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide

There total 3 articles about 2-(1-acetylpiperidin-4-yloxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1420290-87-4
5-chloro-N-(2-chloro-4-nitro-phenyl)-2-(piperidin-4-yloxy)benzamide

: 75-36-5
acetyl chloride

: 1620390-68-2
2-(1-acetylpiperidin-4-yloxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.166667h;

Reference yield:

: 1420290-93-2
4-[4-chloro-2-(2-chloro-4-nitro-phenylcarbamoyl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

: 1620390-68-2
2-(1-acetylpiperidin-4-yloxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

2: triethylamine / dichloromethane / 0.17 h / 0 - 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1620390-68-2
2-(1-acetylpiperidin-4-yloxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

3: triethylamine / dichloromethane / 0.17 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;