Chemical Property of Diallyl trisulfide
Chemical Property:
- Vapor Pressure:0.105mmHg at 25°C
- Refractive Index:1.581
- Boiling Point:229.5 °C at 760 mmHg
- Flash Point:87.8 °C
- PSA：75.90000
- Density:1.116 g/cm3
- LogP:3.38800
- Storage Temp.:-20°C
- XLogP3:2.6
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:6
- Exact Mass:177.99446384
- Heavy Atom Count:9
- Complexity:70.4
- Purity/Quality:
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95% *data from raw suppliers
DiallylTrisulfide(80%) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C=CCSSSCC=C
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Description
Hydrogen sulfide (H2S) is an endogenously-produced gaseous second messenger that can regulate many physiological processes. Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic that acts as an H2S donor. It reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM) and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM). DATS suppresses the growth of PC-3 xenografts in vivo in mice and induces vascular smooth muscle relaxation. Garlic extracts also lower cholesterol and there is evidence that DATS can alter the expression of genes and inhibit enzymes that are relevant to cholesterol synthesis.
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Uses
Diallyl trisulfide (DATS) has been used to study its antimicrobial effects against Campylobacter jejuni. It has also been used to test its effect on hepatic regeneration in partial hepatectomy (PHx) rats. Diallyl Trisulfide, is an organosulfur garlic compound that induces neovasculogenesis and has preventive effects against ischemic injuries. Antiarrythmic effect.
