2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester

Base Information

Chemical Name:2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester
CAS No.:500735-22-8
Molecular Formula:C₂₅H₂₄Cl₂N₄O₅
Molecular Weight:531.395
Hs Code.:

2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3<i>H</i>-benzoimidazol-5-yl]-succinic acid diethyl ester

Synonyms:2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester

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Chemical Property of 2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester

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Technology Process of 2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester

There total 5 articles about 2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1115-30-6
diethyl acetylsuccinate

: 500735-22-8
2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Cs₂CO₃ / dimethylformamide

2.1: H₂ / 10 percent Pd/C / methanol / 2585.74 Torr

3.1: tetrahydrofuran / 5 h / 20 °C

3.2: HgO / tetrahydrofuran

With hydrogen; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020446l

Reference yield:

: 5866-98-8
2,6-dichloro-3-nitrobenzonitrile

: 500735-22-8
2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / ethyl acetate; H₂O / 4.5 h / 10 - 20 °C

2.1: Cs₂CO₃ / dimethylformamide

3.1: H₂ / 10 percent Pd/C / methanol / 2585.74 Torr

4.1: tetrahydrofuran / 5 h / 20 °C

4.2: HgO / tetrahydrofuran

With hydrogen; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020446l

Reference yield:

: 333458-39-2
6-chloro-2-methylamino-3-nitrobenzonitrile

: 500735-22-8
2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Cs₂CO₃ / dimethylformamide

2.1: H₂ / 10 percent Pd/C / methanol / 2585.74 Torr

3.1: tetrahydrofuran / 5 h / 20 °C

3.2: HgO / tetrahydrofuran

With hydrogen; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020446l