N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide
CAS No.:1132937-45-1
Molecular Formula:C₂₄H₂₇N₃O₅S
Molecular Weight:469.561
Hs Code.:

Synonyms:N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide

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Chemical Property of N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide

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Technology Process of N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide

There total 8 articles about N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 111448-81-8
N-(4-ethynylphenyl)methanesulfonamide

: 1132940-49-8
1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione

: 1132937-45-1
N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 80 ℃; for 0.5h;
DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

: 88-18-6
2-tert-Butylphenol

: 1132937-45-1
N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid; acetic acid / cyclohexane / 1 h / 0 °C

2: Iodine monochloride / methanol; water / 2 h / 20 °C

3: methanol; tert-butyl methyl ether; diethyl ether / 16 h / 0 - 20 °C

4: iron; ammonium chloride / water; tetrahydrofuran; ethanol / 2 h / Reflux

5: toluene / 100 °C

6: acetic acid / 24 h / 120 °C

7: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.5 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; nitric acid; Iodine monochloride; iron; ammonium chloride; acetic acid; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; tert-butyl methyl ether; cyclohexane; water; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

: 6683-81-4
2-tert-butyl-4-nitrophenol

: 1132937-45-1
N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: Iodine monochloride / methanol; water / 2 h / 20 °C

2: methanol; tert-butyl methyl ether; diethyl ether / 16 h / 0 - 20 °C

3: iron; ammonium chloride / water; tetrahydrofuran; ethanol / 2 h / Reflux

4: toluene / 100 °C

5: acetic acid / 24 h / 120 °C

6: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.5 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Iodine monochloride; iron; ammonium chloride; acetic acid; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; tert-butyl methyl ether; water; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.7b01630