1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione
• CAS No.: 1132940-49-8
• Molecular Formula: C₁₅H₁₉IN₂O₃
• Molecular Weight: 402.232
• Mol file: 1132940-49-8.mol

Synonyms:1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione

Chemical Property of 1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione

There total 8 articles about 1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-N-(3-tert-butyl-5-iodo-4-methoxyphenylcarbamoyl)-3-methoxy-acrylamide (1132940-47-6) → 1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione (1132940-49-8)

Guidance literature:

With sulfuric acid; In ethanol; water; at 110 ℃; for 2.5h; Product distribution / selectivity;

Reference yield: 66.0%

3-tert-butyl-5-iodo-4-methoxyaniline (1132940-45-4) + urea (57-13-6) + acrylic acid (79-10-7) → 1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione (1132940-49-8)

Guidance literature:

3-tert-butyl-5-iodo-4-methoxyaniline; acrylic acid;

urea; With acetic acid; at 20 ℃; for 24h; Product distribution / selectivity;

Reference yield: 66.0%

C14H20INO3 + urea (57-13-6) → 1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione (1132940-49-8)

Guidance literature:

With acetic acid; at 120 ℃; for 24h;

DOI:10.1021/acs.jmedchem.7b01630

upstream raw materials:

3-tert-butyl-5-iodo-4-methoxyaniline

urea

acrylic acid

(E)-N-(3-tert-butyl-5-iodo-4-methoxyphenylcarbamoyl)-3-methoxy-acrylamide

Downstream raw materials:

1-(3-tert-butyl-4-methoxy-5-(1-oxo-2,3-dihydro-1H-inden-5-yl)phenyl)pyrimidine-2,4(1H,3H)-dione

N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide

N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)quinolin-2-yl)methanesulfonamide

N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide