Uric Acid

Base Information

• Chemical Name: Uric Acid
• CAS No.: 69-93-2
• Deprecated CAS: 13154-20-6,33278-42-1,34318-07-5,42911-25-1,42911-27-3,42911-28-4,530-13-2,34318-07-5,42911-25-1,42911-27-3,42911-28-4,530-13-2
• Molecular Formula: C5H4N4O3
• Molecular Weight: 168.112
• Hs Code.: 29339900
• European Community (EC) Number: 200-720-7
• NSC Number: 3975
• UNII: 268B43MJ25
• DSSTox Substance ID: DTXSID3042508
• Nikkaji Number: J2.372H
• Wikipedia: Uric_acid
• Wikidata: Q105522
• NCI Thesaurus Code: C62652
• Metabolomics Workbench ID: 37183
• ChEMBL ID: CHEMBL792
• Mol file: 69-93-2.mol

Synonyms:2,6,8-Trihydroxypurine;Acid Urate, Ammonium;Acid Urate, Sodium;Acid, Uric;Ammonium Acid Urate;Monohydrate, Monosodium Urate;Monohydrate, Sodium Urate;Monosodium Urate;Monosodium Urate Monohydrate;Potassium Urate;Sodium Acid Urate;Sodium Acid Urate Monohydrate;Sodium Urate;Sodium Urate Monohydrate;Trioxopurine;Urate;Urate Monohydrate, Monosodium;Urate Monohydrate, Sodium;Urate, Ammonium Acid;Urate, Monosodium;Urate, Potassium;Urate, Sodium;Urate, Sodium Acid;Uric Acid

Chemical Property of Uric Acid

Chemical Property:

• Appearance/Colour: Off-white crystals
• Vapor Pressure: 2.63E-31mmHg at 25°C
• Melting Point: >300°C(lit.)
• Refractive Index: 1.721
• Boiling Point: 863 °C at 760 mmHg
• PKA: 3.89(at 12℃)
• Flash Point: 475.7 °C
• PSA: 114.37000
• Density: 1.87 g/cm³
• LogP: -1.76720
• Storage Temp.: Store at RT.
• Solubility.: Aqueous Base (Sparingly, Heated)
• Water Solubility.: Soluble in 1M sodium hydroxide solution. Slightly soluble in water. Insoluble in ether and alcohol.
• XLogP3: -1.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 168.02834000
• Heavy Atom Count: 12
• Complexity: 332

Purity/Quality:

99.9% ^*data from raw suppliers

Uric acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 33-36/37/38
• Safety Statements: 24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Purines
• Canonical SMILES: C12=C(NC(=O)N1)NC(=O)NC2=O
• Recent ClinicalTrials: Efficacy Study of Combined Treatment With Uric Acid and rtPA in Acute Ischemic Stroke
• Recent NIPH Clinical Trials: Beneficial effect by Xanthine oxidase inhibitor on endothelial function beyond Uric Acid trial
• Uses: Uric Acid is a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.

Technology Process of Uric Acid

There total 74 articles about Uric Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(guanin-C8-yl)-1-naphthylamine (80156-61-2) → uric Acid (69-93-2) + 1-amino-naphthalene (134-32-7)

Guidance literature:

With alkali;

DOI:10.1248/cpb.29.2730

Reference yield:

xanthin (69-89-6,6053-41-4) → pyrimidine-2,4,5,6(1H,3H)-tetraone (61066-33-9,61066-34-0,61066-35-1,61127-23-9) + uric Acid (69-93-2) + urea (57-13-6)

Guidance literature:

at 25 ℃; Product distribution; Mechanism; Rate constant; electrochemical oxidation; buffer (pH=2-6); various times, potentials and electrodes;

Reference yield:

→ uric Acid (69-93-2) + Allantoin (97-59-6)

Guidance literature:

With horse-erythrocytes; oxygen;

upstream raw materials:

5,6-diaminouracil

urea

5-hydroxybarbituric acid

(6-amino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-urea

Downstream raw materials:

8-methylxanthine

xanthin

ammelide

5,6-bis-acetylamino-1H-pyrimidine-2,4-dione

Refernces

• 1、 Hall, Richard S.,Fedorov, Alexander A.,Marti-Arbona, Ricardo,Fedorov, Elena V.,Kolb, Peter,Sauder, J. Michael,Burley, Stephen K.,Shoichet, Brian K.,Almo, Steven C.,Raushel, Frank M.. "The hunt for 8-oxoguanine deaminase". . p. 1762 - 1763. Retrieved 2010.
• 2、 Sau, Apurba Kumar,Mondal, Madhu Sudan,Mitra, Samaresh. "Mixed Inhibition of the Oxidoreductase Activity of Xanthine Oxidase by Pd2+ Ion". . p. 1547 - 1548. Retrieved 1994.
• 3、 Horbaczewski. "-". . p. 221. Retrieved 1891.
• 4、 Rahmani, Hossein,Ghavamipour, Fahimeh,Sajedi, Reza H.. "Bioluminescence Detection of Superoxide Anion Using Aequorin". . p. 12768 - 12774. Retrieved 2019.
• 5、 Tsutsui, Yasuhiro,Nakamura, Yukio,Yamaguchi, Shiho,Kawanaka, Nobuyo,Sato, Makoto. "Effects of zinc acexamate (NAS-501) on superoxide radicals and lipid peroxidation of rat gastric mucosa". . p. 209 - 219. Retrieved 1999.
• 6、 Sugiura,Kato,Adachi,Ito,Hirano. "A new method for the assay of xanthine oxidase activity". . p. 430 - 432. Retrieved 1981.
• 7、 Nagao,Seki,Kobayashi. "Inhibition of xanthine oxidase by flavonoids.". . p. 1787 - 1790. Retrieved 1999.
• 8、 Werner,Kapoor. "Behavior of some purine derivatives towards xanthine oxidase". . p. 308 - 309. Retrieved 1966.
• 9、 Shi, Weijie,Fan, Hai,Ai, Shiyun,Zhu, Lusheng. "Pd nanoparticles supported on nitrogen, sulfur-doped three-dimensional hierarchical nanostructures as peroxidase-like catalysts for colorimetric detection of xanthine". . p. 32183 - 32190. Retrieved 2015.
• 10、 Xiong, Zhili,Weng, Yanmin,Lang, Lang,Ma, Shuping,Zhao, Longshan,Xiao, Wei,Wang, Yanjuan. "Tissue metabolomic profiling to reveal the therapeutic mechanism of reduning injection on LPS-induced acute lung injury rats". . p. 10023 - 10031. Retrieved 2018/03/23.