(S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate
CAS No.:1423720-74-4
Molecular Formula:C₂₇H₅₁NO₆Si₂
Molecular Weight:541.876
Hs Code.:

Synonyms:(S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate

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Chemical Property of (S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate

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Technology Process of (S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate

There total 4 articles about (S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1423720-73-3
(S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1423720-74-4
(S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃;
DOI:10.1016/j.tet.2013.02.079

Reference yield:

: 1423720-71-1
(S)-tert-butyl 4-(3,5-diiodo-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1423720-74-4
(S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere

1.2: -78 - 35 °C / Inert atmosphere

1.3: 0 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

3.1: toluene-4-sulfonic acid / methanol / 20 °C

With 1H-imidazole; n-butyllithium; toluene-4-sulfonic acid; In methanol; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.02.079

Reference yield:

: 1423720-72-2
(S)-tert-butyl 4-(3,5-dihydroxy-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1423720-74-4
(S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

2: toluene-4-sulfonic acid / methanol / 20 °C

With 1H-imidazole; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.02.079