(S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate
CAS No.:1423720-73-3
Molecular Formula:C₃₀H₅₅NO₆Si₂
Molecular Weight:581.941
Hs Code.:

Synonyms:(S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

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Chemical Property of (S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

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Technology Process of (S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

There total 3 articles about (S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1423720-72-2
(S)-tert-butyl 4-(3,5-dihydroxy-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1423720-73-3
(S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.tet.2013.02.079

Reference yield:

: 1423720-71-1
(S)-tert-butyl 4-(3,5-diiodo-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1423720-73-3
(S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere

1.2: -78 - 35 °C / Inert atmosphere

1.3: 0 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; In diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.02.079

Reference yield:

: 1426447-08-6
(S)-tert-butyl 4-(3,5-dibromo-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1423720-73-3
(S)-tert-butyl 4-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium

2: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.02.079