(S)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

Base Information

Chemical Name:(S)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
CAS No.:1423720-68-6
Molecular Formula:C₂₇H₄₉NO₇Si₂
Molecular Weight:555.86
Hs Code.:

Synonyms:(S)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

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Chemical Property of (S)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

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Technology Process of (S)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

There total 5 articles about (S)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1423720-74-4
(S)-tert-butyl (1-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-3-hydroxypropan-2-yl)carbamate

: 1423720-68-6
(S)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In water; acetonitrile; at 20 ℃; for 5h;
DOI:10.1016/j.tet.2013.02.079

Reference yield:

: 1423720-71-1
(S)-tert-butyl 4-(3,5-diiodo-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1423720-68-6
(S)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere

1.2: -78 - 35 °C / Inert atmosphere

1.3: 0 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

3.1: toluene-4-sulfonic acid / methanol / 20 °C

4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / acetonitrile; water / 5 h / 20 °C

With 1H-imidazole; n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; toluene-4-sulfonic acid; In methanol; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2013.02.079

Reference yield:

: 1423720-72-2
(S)-tert-butyl 4-(3,5-dihydroxy-4-methoxybenzyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1423720-68-6
(S)-3-(3,5-bis((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

2: toluene-4-sulfonic acid / methanol / 20 °C

3: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / acetonitrile; water / 5 h / 20 °C

With 1H-imidazole; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; toluene-4-sulfonic acid; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2013.02.079