(3'R)-{6-[4'-(tert-butyldimethylsilanyloxy)-3'-hydroxybutyl]-2-methoxypyridin-3-yl}carbamic acid benzyl ester

Base Information

Chemical Name:(3'R)-{6-[4'-(tert-butyldimethylsilanyloxy)-3'-hydroxybutyl]-2-methoxypyridin-3-yl}carbamic acid benzyl ester
CAS No.:343566-74-5
Molecular Formula:C₂₄H₃₆N₂O₅Si
Molecular Weight:460.646
Hs Code.:

Synonyms:(3'R)-{6-[4'-(tert-butyldimethylsilanyloxy)-3'-hydroxybutyl]-2-methoxypyridin-3-yl}carbamic acid benzyl ester

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Chemical Property of (3'R)-{6-[4'-(tert-butyldimethylsilanyloxy)-3'-hydroxybutyl]-2-methoxypyridin-3-yl}carbamic acid benzyl ester

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Technology Process of (3'R)-{6-[4'-(tert-butyldimethylsilanyloxy)-3'-hydroxybutyl]-2-methoxypyridin-3-yl}carbamic acid benzyl ester

There total 4 articles about (3'R)-{6-[4'-(tert-butyldimethylsilanyloxy)-3'-hydroxybutyl]-2-methoxypyridin-3-yl}carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 343566-73-4
(3'R)-[6-(3',4'-dihydroxybutyl)-2-methoxypyridin-3-yl]carbamic acid benzyl ester

: 343566-74-5
(3'R)-{6-[4'-(tert-butyldimethylsilanyloxy)-3'-hydroxybutyl]-2-methoxypyridin-3-yl}carbamic acid benzyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 23 ℃; for 19h;
DOI:10.1021/jo010712n

Reference yield:

: 402829-07-6
(2-methoxy-6-methylpyridin-3-yl)carbamic acid benzyl ester

: 343566-74-5
(3'R)-{6-[4'-(tert-butyldimethylsilanyloxy)-3'-hydroxybutyl]-2-methoxypyridin-3-yl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 12 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 18 h / Heating

2: 37 percent / tetrahydrofuran; diethyl ether / 0 - 50 °C

3: (DHQD)2-AQN; K₃Fe(CN)6; K₂CO₃ / OsO₄ / 2-methyl-propan-2-ol; H₂O / 24 h / 23 °C

4: 82 percent / 4-(dimethylamino)pyridine; Et₃N / CH₂Cl₂ / 19 h / 23 °C

With dmap; N-Bromosuccinimide; (DHQD)2AQN; potassium carbonate; triethylamine; potassium hexacyanoferrate(III); dibenzoyl peroxide; osmium(VIII) oxide; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo010712n

Reference yield:

: 402829-09-8
(6-bromomethyl-2-methoxypyridin-3-yl)carbamic acid benzyl ester

: 343566-74-5
(3'R)-{6-[4'-(tert-butyldimethylsilanyloxy)-3'-hydroxybutyl]-2-methoxypyridin-3-yl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 37 percent / tetrahydrofuran; diethyl ether / 0 - 50 °C

2: (DHQD)2-AQN; K₃Fe(CN)6; K₂CO₃ / OsO₄ / 2-methyl-propan-2-ol; H₂O / 24 h / 23 °C

3: 82 percent / 4-(dimethylamino)pyridine; Et₃N / CH₂Cl₂ / 19 h / 23 °C

With dmap; (DHQD)2AQN; potassium carbonate; triethylamine; potassium hexacyanoferrate(III); osmium(VIII) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo010712n