benzyl 4-[3-(3-ethyl-1-methyl-perhydro-azepin-3-yl)-phenoxycarbamoyl]-3-methoxybenzoate

Base Information

Chemical Name:benzyl 4-[3-(3-ethyl-1-methyl-perhydro-azepin-3-yl)-phenoxycarbamoyl]-3-methoxybenzoate
CAS No.:1314003-67-2
Molecular Formula:C₃₁H₃₆N₂O₅
Molecular Weight:516.637
Hs Code.:

Synonyms:benzyl 4-[3-(3-ethyl-1-methyl-perhydro-azepin-3-yl)-phenoxycarbamoyl]-3-methoxybenzoate

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Chemical Property of benzyl 4-[3-(3-ethyl-1-methyl-perhydro-azepin-3-yl)-phenoxycarbamoyl]-3-methoxybenzoate

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Technology Process of benzyl 4-[3-(3-ethyl-1-methyl-perhydro-azepin-3-yl)-phenoxycarbamoyl]-3-methoxybenzoate

There total 4 articles about benzyl 4-[3-(3-ethyl-1-methyl-perhydro-azepin-3-yl)-phenoxycarbamoyl]-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.6%

: 75-44-5
phosgene

: 190330-56-4
benzyl 4-amino-3-methoxybenzoate

: 59263-76-2
Meptazinol hydrochloride

: 1314003-67-2
benzyl 4-[3-(3-ethyl-1-methyl-perhydro-azepin-3-yl)-phenoxycarbamoyl]-3-methoxybenzoate

Guidance literature:: phosgene; benzyl 4-amino-3-methoxybenzoate; With triethylamine; In tetrahydrofuran; toluene; at -76 - -70 ℃; for 0.755556h; Inert atmosphere;

Meptazinol hydrochloride; In tetrahydrofuran; toluene; at -76 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 100-39-0
benzyl bromide

: 1314003-67-2
benzyl 4-[3-(3-ethyl-1-methyl-perhydro-azepin-3-yl)-phenoxycarbamoyl]-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 21 h / 80 °C / Inert atmosphere

2.1: tin(II) chloride dihdyrate / ethanol / 1.25 h / 80 °C / Inert atmosphere

3.1: triethylamine / toluene; tetrahydrofuran / 0.76 h / -76 - -70 °C / Inert atmosphere

3.2: 1 h / -76 - 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 3.1: Schotten-Baumann Reaction;

Reference yield:

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 1314003-67-2
benzyl 4-[3-(3-ethyl-1-methyl-perhydro-azepin-3-yl)-phenoxycarbamoyl]-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 21 h / 80 °C / Inert atmosphere

2.1: tin(II) chloride dihdyrate / ethanol / 1.25 h / 80 °C / Inert atmosphere

3.1: triethylamine / toluene; tetrahydrofuran / 0.76 h / -76 - -70 °C / Inert atmosphere

3.2: 1 h / -76 - 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 3.1: Schotten-Baumann Reaction;