tert-butyl 4-[[4-(3-ethoxy-3-oxopropyl)isoquinolin-1-yl]meth yl]benzoate

Base Information

Chemical Name:tert-butyl 4-[[4-(3-ethoxy-3-oxopropyl)isoquinolin-1-yl]meth yl]benzoate
CAS No.:1660146-55-3
Molecular Formula:C₂₆H₂₉NO₄
Molecular Weight:419.521
Hs Code.:

Synonyms:tert-butyl 4-[[4-(3-ethoxy-3-oxopropyl)isoquinolin-1-yl]meth yl]benzoate

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Chemical Property of tert-butyl 4-[[4-(3-ethoxy-3-oxopropyl)isoquinolin-1-yl]meth yl]benzoate

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Technology Process of tert-butyl 4-[[4-(3-ethoxy-3-oxopropyl)isoquinolin-1-yl]meth yl]benzoate

There total 7 articles about tert-butyl 4-[[4-(3-ethoxy-3-oxopropyl)isoquinolin-1-yl]meth yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1660146-54-2
tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate

: 1660146-55-3
tert-butyl 4-[[4-(3-ethoxy-3-oxopropyl)isoquinolin-1-yl]meth yl]benzoate

Guidance literature:: With sodium tetrahydroborate; copper dichloride; In methanol; at 0 ℃; for 1h;
DOI:10.1248/cpb.c13-00980

Reference yield:

: 108052-76-2
4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester

: 1660146-55-3
tert-butyl 4-[[4-(3-ethoxy-3-oxopropyl)isoquinolin-1-yl]meth yl]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 1.17 h / 60 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.25 h / -30 - 50 °C

2.2: 2 h / 60 °C

3.1: sodium hydroxide / tetrahydrofuran / 2.5 h / 50 °C

4.1: borane-THF / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: Dess-Martin periodane / chloroform / 1 h / 0 °C

6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

6.2: 1 h

7.1: copper dichloride; sodium tetrahydroborate / methanol / 1 h / 0 °C

With sodium tetrahydroborate; borane-THF; sodium hexamethyldisilazane; sodium hydride; Dess-Martin periodane; sodium hydroxide; copper dichloride; In tetrahydrofuran; methanol; chloroform; toluene;
DOI:10.1248/cpb.c13-00980

Reference yield:

: 1233249-89-2
tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

: 1660146-55-3
tert-butyl 4-[[4-(3-ethoxy-3-oxopropyl)isoquinolin-1-yl]meth yl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.25 h / -30 - 50 °C

1.2: 2 h / 60 °C

2.1: sodium hydroxide / tetrahydrofuran / 2.5 h / 50 °C

3.1: borane-THF / tetrahydrofuran / 1 h / 0 - 20 °C

4.1: Dess-Martin periodane / chloroform / 1 h / 0 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

5.2: 1 h

6.1: copper dichloride; sodium tetrahydroborate / methanol / 1 h / 0 °C

With sodium tetrahydroborate; borane-THF; sodium hexamethyldisilazane; sodium hydride; Dess-Martin periodane; sodium hydroxide; copper dichloride; In tetrahydrofuran; methanol; chloroform;
DOI:10.1248/cpb.c13-00980