tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate

Base Information

Chemical Name:tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate
CAS No.:1660146-54-2
Molecular Formula:C₂₆H₂₇NO₄
Molecular Weight:417.505
Hs Code.:

Synonyms:tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate

Suppliers and Price of tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate

There total 6 articles about tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 1660146-53-1
tert-butyl 4-[(4-formylisoquinolin-1-yl)methyl]benzoate

: 1660146-54-2
tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

tert-butyl 4-[(4-formylisoquinolin-1-yl)methyl]benzoate; In tetrahydrofuran; for 1h;
DOI:10.1248/cpb.c13-00980

Reference yield:

: 108052-76-2
4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester

: 1660146-54-2
tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 1.17 h / 60 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.25 h / -30 - 50 °C

2.2: 2 h / 60 °C

3.1: sodium hydroxide / tetrahydrofuran / 2.5 h / 50 °C

4.1: borane-THF / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: Dess-Martin periodane / chloroform / 1 h / 0 °C

6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

6.2: 1 h

With borane-THF; sodium hexamethyldisilazane; sodium hydride; Dess-Martin periodane; sodium hydroxide; In tetrahydrofuran; chloroform; toluene;
DOI:10.1248/cpb.c13-00980

Reference yield:

: 1233249-89-2
tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

: 1660146-54-2
tert-butyl 4-[[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]isoquinolin-1-yl]methyl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.25 h / -30 - 50 °C

1.2: 2 h / 60 °C

2.1: sodium hydroxide / tetrahydrofuran / 2.5 h / 50 °C

3.1: borane-THF / tetrahydrofuran / 1 h / 0 - 20 °C

4.1: Dess-Martin periodane / chloroform / 1 h / 0 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

5.2: 1 h

With borane-THF; sodium hexamethyldisilazane; sodium hydride; Dess-Martin periodane; sodium hydroxide; In tetrahydrofuran; chloroform;
DOI:10.1248/cpb.c13-00980