Nithiazine

Base Information

Chemical Name:Nithiazine
CAS No.:58842-20-9
Molecular Formula:C5H8 N2 O2 S
Molecular Weight:160.19
Hs Code.:
European Community (EC) Number:611-751-4
UNII:F1T7M9EJMU
DSSTox Substance ID:DTXSID5073587
Nikkaji Number:J491.118K,J674.788D
Wikipedia:Nithiazine
Wikidata:Q7041263
Mol file:58842-20-9.mol

Synonyms:LS-192830;nithiazine;SD 35651;SD 35651, (E)-isomer;SD-35651;SKI-71;tetrahydro-2-(nitromethylene)-2H-1,3-thiazine;WL-35651

Suppliers and Price of Nithiazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Nithiazine
100mg
$ 635.00

AK Scientific
Nithiazine
1g
$ 1807.00

Total 3 raw suppliers

Chemical Property of Nithiazine

Chemical Property:

Vapor Pressure:0.00242mmHg at 25°C
Boiling Point:287.9°C at 760 mmHg
PKA:1.16±0.20(Predicted)
Flash Point:127.9°C
PSA：83.15000
Density:1.387g/cm³
LogP:1.64050
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:160.03064868
Heavy Atom Count:10
Complexity:164

Purity/Quality:

98% ^*data from raw suppliers

Nithiazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CNC(=C[N+](=O)[O-])SC1
Isomeric SMILES:C1CN/C(=C\[N+](=O)[O-])/SC1
Description Nithiazine and other members of the nitromethylene family were shown at an early stage in their development to be cholinergic agonists (and antagonists) by electrophysiology (6). However, unlike nicotine, they mostly act as partial agonists and are open channel blockers, a property resulting from their partial positive charge.
Uses Nithiazine is used as an active ingredient in fly strips (e.g., QuickStrikes Fly Abatement Strip, Sandoz 9023 fly bait station). The strips are most effective against houseflies (Musca domestica). They can be placed in or around the house, animal housing, recycling facilities, or other facilities where abundant houseflies are a nuisance; however, the manufacturer currently does not support residential uses. Nithiazine is a useful building block and insecticide.

Technology Process of Nithiazine

There total 2 articles about Nithiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 462-47-5
mercapto-3 propylamine

: 13623-94-4
1,1-di(methylsulfanyl)-2-nitroethylene

: 58842-20-9
tetrahydro-2-(nitromethylene)-2H-1,3-thiazine

Guidance literature:: In ethanol; at 20 ℃; for 18h;
DOI:10.1007/s11164-012-0769-5

Reference yield:

: 58842-20-9
tetrahydro-2-(nitromethylene)-2H-1,3-thiazine

Guidance literature:

Reference yield: 61.0%

: 58842-20-9
tetrahydro-2-(nitromethylene)-2H-1,3-thiazine

: 123-11-5
4-methoxy-benzaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 1400278-05-8
ethyl 6-amino-8-(4-methoxyphenyl)-9-nitro-2,3,4,8-tetrahydropyrido[2,1-b][1,3]thiazine-7-carboxylate

Guidance literature:: 4-methoxy-benzaldehyde; ethyl 2-cyanoacetate; In ethanol; at 20 ℃; for 0.05h;

With piperidine; In ethanol; at 20 ℃; for 3h;

tetrahydro-2-(nitromethylene)-2H-1,3-thiazine; In ethanol; for 20h; Reflux;
DOI:10.1007/s11164-012-0769-5