tert-butyl 1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylcarbamate

Base Information

Chemical Name:tert-butyl 1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylcarbamate
CAS No.:1430331-44-4
Molecular Formula:C₃₆H₃₅ClN₆O₄S
Molecular Weight:683.231
Hs Code.:

Synonyms:tert-butyl 1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylcarbamate

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Chemical Property of tert-butyl 1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylcarbamate

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Technology Process of tert-butyl 1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylcarbamate

There total 7 articles about tert-butyl 1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1430331-42-2
6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1430331-44-4
tert-butyl 1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylcarbamate

Guidance literature:: 6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)nicotinaldehyde; tert‐butyl piperidin‐4‐ylcarbamate; With acetic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 1430331-37-5
2-(4-chlorophenylamino)benzo[d]oxazol-5-yl benzoate

: 1430331-44-4
tert-butyl 1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; potassium carbonate / tetrahydrofuran / 2 h / 20 °C

2: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 - 90 °C

3: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 - 50 °C

4: acetic acid / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

With hydrogenchloride; methanol; potassium tert-butylate; potassium carbonate; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; dimethyl sulfoxide;

Reference yield:

: 1430331-35-3
3-(3-(4-Chlorophenyl)thioureido)-4-hydroxyphenyl benzoate

: 1430331-44-4
tert-butyl 1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / Reflux

2: methanol; potassium carbonate / tetrahydrofuran / 2 h / 20 °C

3: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 - 90 °C

4: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 - 50 °C

5: acetic acid / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

With hydrogenchloride; methanol; potassium tert-butylate; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; dimethyl sulfoxide;