Technology Process of tert-butyl 3-((1-6,7-dimethoxy-1-napthoyl)piperidin-4-yl)benzyl carbamate
There total 12 articles about tert-butyl 3-((1-6,7-dimethoxy-1-napthoyl)piperidin-4-yl)benzyl carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / acetonitrile; water / 1 h / 90 °C
3.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice
4.1: hydrogen / palladium-on-charcoal / methanol / 1 h
5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C
5.2: 4 h / 20 °C
With
dmap; sodium tetrahydroborate; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide;
tetrakis(triphenylphosphine) palladium(0); nickel(II) chloride hexahydrate; palladium-on-charcoal;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;
- Guidance literature:
-
6,7-dimethoxy-1-naphthalenecarboxylic acid;
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 0 ℃;
for 0.25h;
tert-butyl 3-(piperidin-4-yl)benzylcarbamate;
In
dichloromethane;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice
2.1: hydrogen / palladium-on-charcoal / methanol / 1 h
3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C
3.2: 4 h / 20 °C
With
dmap; sodium tetrahydroborate; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
nickel(II) chloride hexahydrate; palladium-on-charcoal;
In
methanol; dichloromethane;
