(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6,7-dimethoxynaphthalen-1yl)methanone hydrochloride

Base Information

Chemical Name:(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6,7-dimethoxynaphthalen-1yl)methanone hydrochloride
CAS No.:1290053-88-1
Molecular Formula:C₂₅H₂₈N₂O₃*ClH
Molecular Weight:440.97
Hs Code.:

Synonyms:(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6,7-dimethoxynaphthalen-1yl)methanone hydrochloride

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Chemical Property of (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6,7-dimethoxynaphthalen-1yl)methanone hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6,7-dimethoxynaphthalen-1yl)methanone hydrochloride

There total 13 articles about (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6,7-dimethoxynaphthalen-1yl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1290053-88-1
(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6,7-dimethoxynaphthalen-1yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 1 h / 90 °C

3.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice

4.1: hydrogen / palladium-on-charcoal / methanol / 1 h

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C

5.2: 4 h / 20 °C

6.1: hydrogenchloride / dichloromethane; water / 5 h / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium-on-charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;

Reference yield:

: 1290056-84-6
tert-butyl 3-((1-6,7-dimethoxy-1-napthoyl)piperidin-4-yl)benzyl carbamate

: 1290053-88-1
(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6,7-dimethoxynaphthalen-1yl)methanone hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 5h;

Reference yield:

: 286961-24-8
benzyl 1,2,3,6-tetrahydro-4-(trifluoromethylsulphonyloxy)-pyridine-1-carboxylate

: 1290053-88-1
(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6,7-dimethoxynaphthalen-1yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 1 h / 90 °C

2.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice

3.1: hydrogen / palladium-on-charcoal / methanol / 1 h

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C

4.2: 4 h / 20 °C

5.1: hydrogenchloride / dichloromethane; water / 5 h / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium-on-charcoal; In methanol; dichloromethane; water; acetonitrile;