8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoic acid

Base Information

Chemical Name:8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoic acid
CAS No.:261763-68-2
Molecular Formula:C₃₀H₃₃ClN₂O₅
Molecular Weight:537.055
Hs Code.:

8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[<i>e</i>]indol-3-yl)-8-oxo-octanoic acid

Synonyms:8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoic acid

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Chemical Property of 8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoic acid

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Technology Process of 8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoic acid

There total 5 articles about 8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 505-48-6
octane-1,8-dioic acid

: N-(5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-7-yl)-acetamide; hydrochloride

: 261763-68-2
8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoic acid

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 23 ℃; for 12h;
DOI:10.1016/S0968-0896(00)00088-2

Reference yield:

: 286374-31-0
7-amino-5-benzyloxy-1-chloromethyl-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester

: 261763-68-2
8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Et₃N / tetrahydrofuran / 3 h / 0 °C

2: 4N HCl / dioxane / 5 h / 0 - 23 °C

3: 0.1400 g / Et₃N; EDCI / dimethylformamide / 12 h / 23 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1: Acetylation / 2: Hydrolysis / 3: Acylation;
DOI:10.1016/S0968-0896(00)00088-2

Reference yield:

: 222835-55-4
N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

: 261763-68-2
8-(7-acetylamino-5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-8-oxo-octanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / n-Bu₃SnH; AIBN / benzene / 4 h / Heating

2: 96 percent / TBAF / tetrahydrofuran / 1 h / 23 °C

3: 92 percent / Et₃N / tetrahydrofuran / 3 h / 0 °C

4: 4N HCl / dioxane / 5 h / 0 - 23 °C

5: 0.1400 g / Et₃N; EDCI / dimethylformamide / 12 h / 23 °C

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; benzene; 1: Cyclization / 2: Substitution / 3: Acetylation / 4: Hydrolysis / 5: Acylation;
DOI:10.1016/S0968-0896(00)00088-2