tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)carbamate

Base Information

• Chemical Name: tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)carbamate
• CAS No.: 1388891-81-3
• Molecular Formula: C₂₀H₂₇N₃O₃S
• Molecular Weight: 389.519

Synonyms:tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)carbamate

Chemical Property of tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)carbamate

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Technology Process of tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)carbamate

There total 1 articles about tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine (300816-22-2) + trans-tert-butyl 4-hydroxycyclohexylcarbamate (111300-06-2) → tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-yloxy]cyclohexyl)carbamate (1388891-81-3)

Guidance literature:

trans-tert-butyl 4-hydroxycyclohexylcarbamate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine; In tetrahydrofuran; mineral oil; at 20 ℃; for 5h; Inert atmosphere;

Reference yield: 83.0%

tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-yloxy]cyclohexyl)carbamate (1388891-81-3) + methyl iodide (74-88-4) → tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(12),2(6),8,10-tetraen-12-yloxy]cyclohexyl)carbamate (1388891-87-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield: 80.0%

tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-yloxy]cyclohexyl)carbamate (1388891-81-3) + ethyl iodide (75-03-6) → tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate (1388891-79-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

upstream raw materials:

4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine

trans-tert-butyl 4-hydroxycyclohexylcarbamate

Downstream raw materials:

tert-butyl N-methyl-N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽¹²⁾,2⁽⁶⁾,8,10-tetraen-12-yloxy]cyclohexyl)carbamate

tert-butyl {(1r,4r)-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}(ethyl)carbamate

(1r,4r)-N-benzyl-N-ethyl-4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexan-1-amine

trans-1-(pyrrolidin-1-yl)-2-[(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)amino]ethan-1-one

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