Dimethoxyphosphoryl-(4-methoxyphenyl)methanone

Base Information

• Chemical Name: Dimethoxyphosphoryl-(4-methoxyphenyl)methanone
• CAS No.: 10570-48-6
• Molecular Formula: C10H13 O5 P
• Molecular Weight: 244.184
• Hs Code.: 2931900090
• NSC Number: 169641
• DSSTox Substance ID: DTXSID90305192
• Nikkaji Number: J452.654F
• Wikidata: Q82051688
• Mol file: 10570-48-6.mol

Synonyms:10570-48-6;dimethoxyphosphoryl-(4-methoxyphenyl)methanone;Dimethyl (4-methoxybenzoyl)phosphonate;DIMETHYL(4-METHOXYPHENYLOXOMETHYL)PHOSPHONATE;Phosphonic acid,P-(4-methoxybenzoyl)-, dimethyl ester;(p-Methoxy-Benzoyl)-phosphonic acid dimethyl ester;dimethyl 4-methoxybenzoylphosphonate;NSC169641;SCHEMBL4610734;DTXSID90305192;TYYKVIUTXZKDQU-UHFFFAOYSA-N;(S)-(+)-4-Methoxy-mandelonitrile;MFCD00800267;AKOS017343660;NSC-169641;(4-Methoxy-benzoyl)-phosphonic acid dimethyl ester

Chemical Property of Dimethoxyphosphoryl-(4-methoxyphenyl)methanone

Chemical Property:

• Vapor Pressure: 0.000106mmHg at 25°C
• Boiling Point: 337.2°Cat760mmHg
• Flash Point: 171.5°C
• PSA: 71.64000
• Density: 1.231g/cm³
• LogP: 2.32130
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 244.05006051
• Heavy Atom Count: 16
• Complexity: 275

Purity/Quality:

98%,99%, ^*data from raw suppliers

DIMETHYL(4-METHOXYPHENYLOXOMETHYL)PHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)P(=O)(OC)OC

Technology Process of Dimethoxyphosphoryl-(4-methoxyphenyl)methanone

There total 2 articles about Dimethoxyphosphoryl-(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methoxy-benzoyl chloride (100-07-2) + phosphorous acid trimethyl ester (121-45-9) → dimethyl 4-methoxybenzoylphosphonate (10570-48-6)

Guidance literature:

In toluene;

Reference yield:

→ dimethyl 4-methoxybenzoylphosphonate (10570-48-6)

Guidance literature:

p-Methoxybenzoylchlorid, Trimethylphosphin (Trimethylphosphit);

DOI:10.1139/v73-170

Reference yield: 96.0%

dimethyl 4-methoxybenzoylphosphonate (10570-48-6) + tris(trimethylsilyl) phosphite (1795-31-9) → [(dimethoxy-phosphoryl)-hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid

Guidance literature:

dimethyl 4-methoxybenzoylphosphonate; tris(trimethylsilyl) phosphite; at 25 ℃;

With methanol; Further stages.;

DOI:10.1016/j.tetlet.2004.04.047

upstream raw materials:

4-methoxy-benzoyl chloride

phosphorous acid trimethyl ester

Downstream raw materials:

syn-p-Anisoylphosphonsaeuredimethylester-p-tosylhydrazon

anti-p-Anisoylphosphonsaeuredimethylester-p-tosylhydrazon

[(R)-4-Methoxy-5-(4-methoxy-phenyl)-3-methyl-2,4-dioxo-4λ⁵-[1,3,4]oxazaphospholidin-5-yl]-phosphonic acid dimethyl ester

4-methoxybenzonitrile

Refernces

• 1、 Migianu, Evelyne,Mallard, Isabelle,Bouchemal, Nadia,Lecouvey, Marc. "One-pot synthesis of 1-hydroxymethylene-1,1-bisphosphonate partial esters". . p. 4511 - 4513. Retrieved 2004.
• 2、 Deschamp, Julia,Dussart-Gautheret, Jade,Lecouvey, Marc,Legigan, Thibaut,Migianu-Griffoni, Evelyne,Monteil, Maelle. "One-pot synthesis of phosphinylphosphonate derivatives and their anti-tumor evaluations". . . Retrieved 2021/12/24.
• 3、 Zhou, Yujing,Zhang, Yan,Wang, Jianbo. "Geminal difunctionalization of α-diazo arylmethylphosphonates: Synthesis of fluorinated phosphonates". . p. 10444 - 10453. Retrieved 2016/11/18.