4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-ethyl oxime

Base Information

Chemical Name:4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-ethyl oxime
CAS No.:1586758-79-3
Molecular Formula:C₁₈H₁₆F₂N₂O₂
Molecular Weight:330.334
Hs Code.:

Synonyms:4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-ethyl oxime

Suppliers and Price of 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-ethyl oxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-ethyl oxime

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-ethyl oxime

There total 8 articles about 4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-ethyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1586758-78-2
N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide

: 75-03-6
ethyl iodide

: 1586758-79-3
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-ethyl oxime

Guidance literature:: N-(2-chloro-1-(4-((hydroxyimino)methyl)phenyl)-ethyl)-2,6-difluorobenzamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

ethyl iodide; In N,N-dimethyl-formamide; for 2h;
DOI:10.1021/jf500461a DOI:10.1021/jf500461a

Reference yield:

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 1586758-79-3
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-ethyl oxime

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride / ethanol / 8 h / Reflux

2.1: sodium tetrahydroborate; iodine / tetrahydrofuran / 11.5 h / 0 °C / Reflux

2.2: 5 h / Reflux

3.1: triethylamine / tetrahydrofuran / 7.5 h / 0 - 20 °C

4.1: thionyl chloride / chloroform / 2.83 h / Reflux

5.1: sulfuric acid; chromium(VI) oxide; acetic acid / 6 h

6.1: triethylamine; hydroxylamine hydrochloride / tetrahydrofuran / 4 h / Molecular sieve; Reflux

7.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

7.2: 2 h

With chromium(VI) oxide; sodium tetrahydroborate; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; iodine; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jf500461a

Reference yield:

: 1586758-76-0
N-(2-chloro-1-(p-tolyl)ethyl)-2,6-difluorobenzamide

: 1586758-79-3
4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzaldehyde O-ethyl oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; chromium(VI) oxide; acetic acid / 6 h

2.1: triethylamine; hydroxylamine hydrochloride / tetrahydrofuran / 4 h / Molecular sieve; Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 2 h

With chromium(VI) oxide; sulfuric acid; hydroxylamine hydrochloride; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jf500461a