1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethanamine

Base Information

Chemical Name:1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethanamine
CAS No.:1283090-80-1
Molecular Formula:C₂₀H₂₆F₄N₂OSi
Molecular Weight:414.518
Hs Code.:

Synonyms:1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethanamine

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Chemical Property of 1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethanamine

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Technology Process of 1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethanamine

There total 6 articles about 1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1283090-79-8
{6-[1-amino-1-(3,4-difluorophenyl)-2,2-difluoroethyl]pyridin-3-yl}methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1283090-80-1
1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethanamine

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1017599-17-5
(3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone

: 1283090-80-1
1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2.2: 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

4.1: sodium acetate; magnesium; acetic acid / N,N-dimethyl-formamide; water / 4 h / 20 °C

5.1: hydrogenchloride; water / methanol / 1 h / 20 °C

6.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; hydrogenchloride; titanium(IV) tetraethanolate; water; sodium acetate; magnesium; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1189175-69-6
(3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone

: 1283090-80-1
1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

1.2: 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

3.1: sodium acetate; magnesium; acetic acid / N,N-dimethyl-formamide; water / 4 h / 20 °C

4.1: hydrogenchloride; water / methanol / 1 h / 20 °C

5.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; hydrogenchloride; titanium(IV) tetraethanolate; water; sodium acetate; magnesium; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;