(3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone

Base Information Edit

Chemical Name:(3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone
CAS No.:1189175-69-6
Molecular Formula:C₁₉H₂₃F₂NO₂Si
Molecular Weight:363.479
Hs Code.:
Mol file:1189175-69-6.mol

Synonyms:(3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone

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Chemical Property of (3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone Edit

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Technology Process of (3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone

There total 3 articles about (3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 145733-53-5
2-bromo-5-(tert-butyldimethylsilyloxy methyl)-pyridine

: 188345-25-7
3,4-difluoro-N-methoxy-N-methylbenzamide

: 1189175-69-6
(3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone

Guidance literature:: 2-bromo-5-(tert-butyldimethylsilyloxy methyl)-pyridine; With n-butyllithium; In hexane; toluene; at -78 ℃; for 2h;

3,4-difluoro-N-methoxy-N-methylbenzamide; In hexane; toluene; at -78 - 0 ℃; for 19h;
DOI:10.1016/j.bmcl.2009.07.132

Reference yield:

: 226260-00-0
3,4,5-trifluoro-N-methoxy-N-methylbenzamide

: 145733-53-5
2-bromo-5-(tert-butyldimethylsilyloxy methyl)-pyridine

: 1189175-69-6
(3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone

Guidance literature:: 2-bromo-5-(tert-butyldimethylsilyloxy methyl)-pyridine; With n-butyllithium; In hexane; toluene; at -78 ℃;

3,4,5-trifluoro-N-methoxy-N-methylbenzamide; In hexane; toluene; at -78 - 0 ℃; for 20h;