N-{1-(3,4-difluorophenyl)-2,2-difluoro-1-[5-(hydroxymethyl)pyridin-2-yl]ethyl}acetamide

Base Information

Chemical Name:N-{1-(3,4-difluorophenyl)-2,2-difluoro-1-[5-(hydroxymethyl)pyridin-2-yl]ethyl}acetamide
CAS No.:1283090-76-5
Molecular Formula:C₁₆H₁₄F₄N₂O₂
Molecular Weight:342.293
Hs Code.:

Synonyms:N-{1-(3,4-difluorophenyl)-2,2-difluoro-1-[5-(hydroxymethyl)pyridin-2-yl]ethyl}acetamide

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Chemical Property of N-{1-(3,4-difluorophenyl)-2,2-difluoro-1-[5-(hydroxymethyl)pyridin-2-yl]ethyl}acetamide

Chemical Property:

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Technology Process of N-{1-(3,4-difluorophenyl)-2,2-difluoro-1-[5-(hydroxymethyl)pyridin-2-yl]ethyl}acetamide

There total 8 articles about N-{1-(3,4-difluorophenyl)-2,2-difluoro-1-[5-(hydroxymethyl)pyridin-2-yl]ethyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1283090-81-2
N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difIuorophenyl)-2,2-difluoroethyl]acetamide

: 1283090-76-5
N-{1-(3,4-difluorophenyl)-2,2-difluoro-1-[5-(hydroxymethyl)pyridin-2-yl]ethyl}acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1017599-17-5
(3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone

: 1283090-76-5
N-{1-(3,4-difluorophenyl)-2,2-difluoro-1-[5-(hydroxymethyl)pyridin-2-yl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2.2: 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

4.1: sodium acetate; magnesium; acetic acid / N,N-dimethyl-formamide; water / 4 h / 20 °C

5.1: hydrogenchloride; water / methanol / 1 h / 20 °C

6.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

7.1: 1,2-dichloro-ethane / 3 h / Reflux

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With 1H-imidazole; hydrogenchloride; titanium(IV) tetraethanolate; tetrabutyl ammonium fluoride; water; sodium acetate; magnesium; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1283090-78-7
N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide

: 1283090-76-5
N-{1-(3,4-difluorophenyl)-2,2-difluoro-1-[5-(hydroxymethyl)pyridin-2-yl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / methanol / 1 h / 20 °C

2: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

3: 1,2-dichloro-ethane / 3 h / Reflux

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With 1H-imidazole; hydrogenchloride; tetrabutyl ammonium fluoride; water; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;