3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate)

Base Information

• Chemical Name: 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate)
• CAS No.: 121768-15-8
• Molecular Formula: C₃₇H₄₈ClN₈O₈PSi₂
• Molecular Weight: 855.435
• Mol file: 121768-15-8.mol

Synonyms:3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate)

Chemical Property of 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate)

There total 1 articles about 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N6-benzoyladenosine (79154-57-7) + 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N(6)-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate) (121768-15-8)

Guidance literature:

In tetrahydrofuran; for 18h; Ambient temperature;

Reference yield: 99.0%

3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N(6)-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate) (121768-15-8) → 3',5'-O-(1,1,3,3,-tetraisopropyldisiloxane-1,3-diyl)-N(6)-benzoyladenosine-2' (2-chlorophenyl) phosphate triethylammonium salt (79154-56-6)

Guidance literature:

With triethylamine carbonate; In tetrahydrofuran; water;

Reference yield: 80.0%

3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N(6)-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate) (121768-15-8) + 6-N-benzoyl-9-(2,3-O-ethoxymethylidene-β-D-ribofuranosyl)adenine (10280-24-7) → C55H66ClN10O14PSi2 (121798-66-1)

Guidance literature:

With dmap; In tetrahydrofuran; pyridine; toluene; for 18h;

upstream raw materials:

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

Downstream raw materials:

3',5'-O-(1,1,3,3,-tetraisopropyldisiloxane-1,3-diyl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) phosphate triethylammonium salt

C₅₅H₆₆ClN₁₀O₁₄PSi₂

3'-O-(1,1,3,3-tetraisopropyldisiloxane-1-yl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) (2-cyanoethyl) phosphate