1,3-dihydro-3-methyl-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one

Base Information

Chemical Name:1,3-dihydro-3-methyl-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one
CAS No.:127555-44-6
Molecular Formula:C₂₀H₁₆N₂OS
Molecular Weight:332.426
Hs Code.:

Synonyms:1,3-dihydro-3-methyl-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one

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Chemical Property of 1,3-dihydro-3-methyl-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one

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Technology Process of 1,3-dihydro-3-methyl-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one

There total 7 articles about 1,3-dihydro-3-methyl-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144-55-8
sodium hydrogencarbonate

: 127555-39-9
1,3-dihydro-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one

: 74-88-4
methyl iodide

: 127555-44-6
1,3-dihydro-3-methyl-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one

Guidance literature:: With NaH; In tetrahydrofuran;

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 127555-44-6
1,3-dihydro-3-methyl-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine, p-TsOH / H₂O / Heating

2: LiAlH₄ / tetrahydrofuran / 24 h / Heating

3: SOCl₂ / CH₂Cl₂ / 16 h / Ambient temperature

4: NaOH / ethanol; H₂O / 16 h / Ambient temperature

6: 1.) NaH / 1.) THF, RT, 30 min, 2.) RT, 16 h

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00172a004

Reference yield:

: 16344-24-4
2-(phenylamino)nicotinic acid

: 127555-44-6
1,3-dihydro-3-methyl-1-phenyl-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: LiAlH₄ / tetrahydrofuran / 24 h / Heating

2: SOCl₂ / CH₂Cl₂ / 16 h / Ambient temperature

3: NaOH / ethanol; H₂O / 16 h / Ambient temperature

5: 1.) NaH / 1.) THF, RT, 30 min, 2.) RT, 16 h

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00172a004