6-(3-amino-5-bromophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride

Base Information

Chemical Name:6-(3-amino-5-bromophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride
CAS No.:145235-67-2
Molecular Formula:C₁₁H₁₂BrN₃S*2ClH
Molecular Weight:371.128
Hs Code.:

Synonyms:6-(3-amino-5-bromophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride

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Chemical Property of 6-(3-amino-5-bromophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride

Chemical Property:

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Technology Process of 6-(3-amino-5-bromophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride

There total 4 articles about 6-(3-amino-5-bromophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 145235-67-2
6-(3-amino-5-bromophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / dimethylformamide / 3 h / Heating

2: 2.) 48percent HBr / 1.) CHCl₃, ether, from -50 deg C to RT, 2.) CH₂Cl₂, RT, 1 h

3: acetone / 1.) RT, 1 h, 2.) reflux, 0.5 h

4: NaBH₄ / methanol / 1 h / Ambient temperature

5: SOCl₂ / CHCl₃ / 1 h / Heating

6: aq. K₂CO₃ / CHCl₃ / 1 h / Heating

7: SnCl₂*2H₂O, conc. HCl / 1.) 40 deg C, 1 h, 2.) 70 deg C, 1.5 h

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; hydrogen bromide; potassium carbonate; tin(ll) chloride; In methanol; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0223-5234(92)90184-3

Reference yield:

: 145028-77-9
1-(3-Bromo-5-nitro-phenyl)-2-(2-imino-thiazolidin-3-yl)-ethanol

: 145235-67-2
6-(3-amino-5-bromophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CHCl₃ / 1 h / Heating

2: aq. K₂CO₃ / CHCl₃ / 1 h / Heating

3: SnCl₂*2H₂O, conc. HCl / 1.) 40 deg C, 1 h, 2.) 70 deg C, 1.5 h

With hydrogenchloride; thionyl chloride; potassium carbonate; tin(ll) chloride; In chloroform;
DOI:10.1016/0223-5234(92)90184-3

Reference yield:

: 145028-82-6
3-[2-(3-Bromo-5-nitro-phenyl)-2-chloro-ethyl]-thiazolidin-2-ylideneamine

: 145235-67-2
6-(3-amino-5-bromophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: aq. K₂CO₃ / CHCl₃ / 1 h / Heating

2: SnCl₂*2H₂O, conc. HCl / 1.) 40 deg C, 1 h, 2.) 70 deg C, 1.5 h

With hydrogenchloride; potassium carbonate; tin(ll) chloride; In chloroform;
DOI:10.1016/0223-5234(92)90184-3