methyl (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate

Base Information

Chemical Name:methyl (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate
CAS No.:130796-38-2
Molecular Formula:C₁₄H₁₈O₅
Molecular Weight:266.294
Hs Code.:

Synonyms:methyl (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate

Chemical Property:

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Technology Process of methyl (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate

There total 20 articles about methyl (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 130796-33-7
(4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid

: 130796-38-2
methyl (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate

Guidance literature:: In diethyl ether; at 0 ℃; for 0.166667h;

Reference yield: 98.0%

: 130796-36-0
(4R,5R)-5-(4-Methoxy-phenyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid (S)-1-methyl-heptyl ester

: 127489-32-1,130796-33-7,130796-34-8
cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid

: 122431-48-5,130796-38-2,130796-39-3
methyl cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate

Guidance literature:: In diethyl ether; at 0 ℃; for 0.166667h;

Reference yield:

: 130796-19-9,55000-34-5
methyl 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

: 122431-48-5,130796-38-2,130796-39-3
methyl cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LDA / 1.) hexane, THF, -78 deg C, 30 min, 2.) -78 deg C, 30 min

2: 95 percent / 1 M hydrochloric acid / 18 h / Ambient temperature

3: 100 percent / NaBH₄ / ethanol / 0.67 h / Ambient temperature

4: 88 percent / 4-toluenesulfonic acid / Ambient temperature

5: 94 percent / yellow mercuric oxide, BF₃*Et₂O / tetrahydrofuran; H₂O / 1 h / Ambient temperature

6: 75 percent / silver oxide / Ambient temperature

7: 98 percent / diethyl ether / 0.17 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; mercury(II) oxide; silver(l) oxide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; water;