(S)-2-(trimethylsilyl)piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (S)-2-(trimethylsilyl)piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 408331-89-5
• Molecular Formula: C₁₃H₂₇NO₂Si
• Molecular Weight: 257.448
• Mol file: 408331-89-5.mol

Synonyms:(S)-2-(trimethylsilyl)piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of (S)-2-(trimethylsilyl)piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of (S)-2-(trimethylsilyl)piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about (S)-2-(trimethylsilyl)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + t-butyl piperidinecarboxylate (75844-69-8) + dimethyl sulfate (77-78-1) → (+)-(S)-N-tert-butoxycarbonyl-2-methylpiperidine (183903-99-3) + tert-butyl (2R)-(-)-methylpiperidine-1-carboxylate (191013-97-5) + tert-butyl (R)-2-(trimethylsilyl)piperidine-1-carboxylate (906371-08-2) + (S)-2-(trimethylsilyl)piperidine-1-carboxylic acid tert-butyl ester (408331-89-5)

Guidance literature:

Multistep reaction.;

DOI:10.1039/b710066c

Reference yield:

(S)-2-(trimethylsilyl)piperidine-1-carboxylic acid tert-butyl ester (408331-89-5) → 4-bromophenyl-[2-(trimethylsilyl)piperidin-1-yl]-methanone

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 3 h / 20 °C

2: 241 mg / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja012169y

upstream raw materials:

chloro-trimethyl-silane

t-butyl piperidinecarboxylate

dimethyl sulfate