N-{4-[2-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-trifluoromethyl-benzamide

Base Information

• Chemical Name: N-{4-[2-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-trifluoromethyl-benzamide
• CAS No.: 875798-27-9
• Molecular Formula: C₂₂H₁₆BrF₃N₄OS
• Molecular Weight: 521.36
• Mol file: 875798-27-9.mol

Synonyms:N-{4-[2-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-trifluoromethyl-benzamide

Chemical Property of N-{4-[2-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-trifluoromethyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-{4-[2-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-trifluoromethyl-benzamide

There total 1 articles about N-{4-[2-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-4-chlorothiopheno[3,2-D]pyrimidine (225385-03-5) → N-{4-[2-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-trifluoromethyl-benzamide (875798-27-9)

Guidance literature:

{2-[4-(3-trifluoromethyl-benzoylamino)-phenyl]-ethyl}-carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 2h;

6-bromo-4-chlorothiopheno[3,2-D]pyrimidine; With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 135 ℃; for 2h;

Reference yield: 17.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + N-{4-[2-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-trifluoromethyl-benzamide (875798-27-9) → C25H24F3N5O2S (875797-88-9)

Guidance literature:

In dimethyl sulfoxide; at 150 ℃;

Reference yield:

methanol (67-56-1) + N-{4-[2-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-trifluoromethyl-benzamide (875798-27-9) + carbon monoxide (201230-82-2) → 4-{2-[4-(3-trifluoromethyl-benzoylamino)-phenyl]-ethylamino}-thieno[3,2-d]pyrimidine-6-carboxylic acid methyl ester (875798-32-6)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 3.83333h;

upstream raw materials:

6-bromo-4-chlorothiopheno[3,2-D]pyrimidine

Downstream raw materials:

4-{2-[4-(3-trifluoromethyl-benzoylamino)-phenyl]-ethylamino}-thieno[3,2-d]pyrimidine-6-carboxylic acid methyl ester

C₂₅H₂₄F₃N₅O₂S