4-((1r,4r)-4-(l-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile

Base Information

Chemical Name:4-((1r,4r)-4-(l-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile
CAS No.:1415818-26-6
Molecular Formula:C₂₀H₂₂F₃N₅O₃
Molecular Weight:437.422
Hs Code.:

Synonyms:4-((1r,4r)-4-(l-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile

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Chemical Property of 4-((1r,4r)-4-(l-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile

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Technology Process of 4-((1r,4r)-4-(l-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile

There total 8 articles about 4-((1r,4r)-4-(l-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1415818-28-8
(1r,4r)-4-(1-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexanol

: 89284-61-7
4-chloro-nicotinonitrile

: 1415818-26-6
4-((1r,4r)-4-(l-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 0.5h; Inert atmosphere; Cooling with ice;

Reference yield:

: 1338556-37-8
(1r,4r)-4-(pyridin-4-yloxy)cyclohexanol

: 1415818-26-6
4-((1r,4r)-4-(l-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: ISOPROPYLAMIDE; tetrahydrofuran

2.1: sodium tetrahydroborate; methanol / 20 °C / Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 2585.81 Torr

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: hydroxylamine / ethanol / 4 h / 75 °C

6.1: triethylamine / dichloromethane / 1 h / 35 °C

6.2: 1 h / 20 °C

7.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

With methanol; sodium tetrahydroborate; potassium tert-butylate; hydrogen; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 1415817-97-8
4-((1r,4r)-4-hydroxycyclohexyloxy)-1-methylpyridinium iodide

: 1415818-26-6
4-((1r,4r)-4-(l-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate; methanol / 20 °C / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 2585.81 Torr

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: hydroxylamine / ethanol / 4 h / 75 °C

5.1: triethylamine / dichloromethane / 1 h / 35 °C

5.2: 1 h / 20 °C

6.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

With methanol; sodium tetrahydroborate; potassium tert-butylate; hydrogen; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane;