1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate
• CAS No.: 960001-08-5
• Molecular Formula: C₂₂H₃₃NO₅
• Molecular Weight: 391.508
• Mol file: 960001-08-5.mol

Synonyms:1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate

Chemical Property of 1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate

There total 2 articles about 1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(3-hydroxy-phenyl)methyl 2,2-dimethyl-propanoate (960001-07-4) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate (960001-08-5)

Guidance literature:

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In water-d2; at 0 - 20 ℃; for 18.0833h;

Reference yield:

3-Hydroxybenzyl alcohol (620-24-6) + 3-pivaloyl-1,3-thiazolidine-2-thione (138459-91-3) → 1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate (960001-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 18 h / Heating / reflux

2: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 18.08 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; toluene;

Reference yield: 90.0%

1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate (960001-08-5) → tert-butyl 4-(3-(hydroxymethyl)phenoxy)piperidine-1-carboxylate (321337-39-7)

Guidance literature:

With lithium hydroxide; water; In 1,4-dioxane; at 20 - 50 ℃; for 3.5h;

upstream raw materials:

(3-hydroxy-phenyl)methyl 2,2-dimethyl-propanoate

t-butyl 4-hydroxy piperidine-1-carboxylate

3-Hydroxybenzyl alcohol

3-pivaloyl-1,3-thiazolidine-2-thione

Downstream raw materials:

tert-butyl 4-(3-(hydroxymethyl)phenoxy)piperidine-1-carboxylate

tert-butyl 4-(3-formylphenoxy)piperidine-1-carboxylate

(+/-)-1,1-dimethylethyl 4-{[3-(1-hydroxyethyl)phenyl]oxy}-1-piperidinecarboxylate