2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester
CAS No.:202062-70-2
Molecular Formula:C₄₆H₆₀O₈Si
Molecular Weight:769.063
Hs Code.:

2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester

Synonyms:2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester

There total 9 articles about 2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 3282-30-2
pivaloyl chloride

: 202062-63-3
(1S,2S,4S,5R,6R)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-1-hydroxymethyl-5-(4-methoxy-benzyloxymethyl)-5-methyl-cyclohexane-1,2-diol

: 202062-70-2
2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester

Guidance literature:: With dmap; In dichloromethane; 0 deg C up to RT;
DOI:10.1016/S0040-4039(97)10554-8

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 202062-70-2
2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / PPTS / CH₂Cl₂ / 24 h / Ambient temperature

2: 69 percent / BF₃*OEt₂, 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / -60 °C

3: LiAlH₄ / diethyl ether / 1 h / 0 deg C up to RT

4: 97 percent / imidazole / CH₂Cl₂ / 0 deg C up to RT

5: 99 percent / nBu₄NI, KH / tetrahydrofuran / Ambient temperature

6: 84 percent / SeO₂, 70percent TBHP, salicylic acid / CH₂Cl₂ / 12 h / Ambient temperature

7: 82 percent / OsO₄, Me₃NO / acetone; H₂O / 36 h / Ambient temperature

8: 97 percent / DMAP / CH₂Cl₂ / 0 deg C up to RT

With 1H-imidazole; tert.-butylhydroperoxide; dmap; osmium(VIII) oxide; lithium aluminium tetrahydride; selenium(IV) oxide; trimethylamine-N-oxide; 4 A molecular sieve; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; potassium hydride; salicylic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(97)10554-8

Reference yield:

: 202062-65-5
(1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

: 202062-70-2
2,2-Dimethyl-propionic acid (1S,2R,3R,4S,6S)-4-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-1,6-dihydroxy-3-(4-methoxy-benzyloxymethyl)-3-methyl-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / imidazole / CH₂Cl₂ / 0 deg C up to RT

2: 99 percent / nBu₄NI, KH / tetrahydrofuran / Ambient temperature

3: 84 percent / SeO₂, 70percent TBHP, salicylic acid / CH₂Cl₂ / 12 h / Ambient temperature

4: 82 percent / OsO₄, Me₃NO / acetone; H₂O / 36 h / Ambient temperature

5: 97 percent / DMAP / CH₂Cl₂ / 0 deg C up to RT

With 1H-imidazole; tert.-butylhydroperoxide; dmap; osmium(VIII) oxide; selenium(IV) oxide; trimethylamine-N-oxide; tetra-(n-butyl)ammonium iodide; potassium hydride; salicylic acid; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(97)10554-8