(1S,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

Base Information

Chemical Name:(1S,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol
CAS No.:202062-66-6
Molecular Formula:C₃₄H₄₄O₄Si
Molecular Weight:544.806
Hs Code.:

Synonyms:(1S,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

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Chemical Property of (1S,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

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Technology Process of (1S,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

There total 5 articles about (1S,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 202062-65-5
(1S,2R,3R)-3-Hydroxymethyl-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

: 202062-66-6
(1S,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

Guidance literature:: With 1H-imidazole; In dichloromethane; 0 deg C up to RT;
DOI:10.1016/S0040-4039(97)10554-8

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 202062-66-6
(1S,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / PPTS / CH₂Cl₂ / 24 h / Ambient temperature

2: 69 percent / BF₃*OEt₂, 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / -60 °C

3: LiAlH₄ / diethyl ether / 1 h / 0 deg C up to RT

4: 97 percent / imidazole / CH₂Cl₂ / 0 deg C up to RT

With 1H-imidazole; lithium aluminium tetrahydride; 4 A molecular sieve; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(97)10554-8

Reference yield:

: 202062-60-0
(1R,2R,3S)-3-Hydroxy-2-(4-methoxy-benzyloxymethyl)-2-methyl-6-methylene-cyclohexanecarboxylic acid methyl ester

: 202062-66-6
(1S,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxymethyl)-2-methyl-4-methylene-cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 1 h / 0 deg C up to RT

2: 97 percent / imidazole / CH₂Cl₂ / 0 deg C up to RT

With 1H-imidazole; lithium aluminium tetrahydride; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(97)10554-8