N-methyl-1-phenylmethanesulfonamide

Base Information

• Chemical Name: N-methyl-1-phenylmethanesulfonamide
• CAS No.: 19299-41-3
• Molecular Formula: C8H11NO2S
• Molecular Weight: 185.247
• Mol file: 19299-41-3.mol

Synonyms:

Chemical Property of N-methyl-1-phenylmethanesulfonamide

Chemical Property:

• Vapor Pressure: 0.000478mmHg at 25°C
• Boiling Point: 314°C at 760 mmHg
• Flash Point: 143.7°C
• Density: 1.217g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-methyl-1-phenylmethanesulfonamide

There total 13 articles about N-methyl-1-phenylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + phenyl-methanesulfonic acid amide (4563-33-1) → N-methyl-1-phenylmethanesulfonamide (19299-41-3)

Guidance literature:

With [Cp*Ir(2-(1H-benzo[d]imidazol-2-yl)-1H-benzo[d]imidazole)Cl][Cl]; caesium carbonate; at 120 ℃; for 12h; Schlenk technique;

DOI:10.1021/acs.orglett.7b02723

Reference yield: 85.0%

C16H19NO3S (950017-96-6) → N-methyl-1-phenylmethanesulfonamide (19299-41-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ol800785g

Reference yield: 74.0%

methylamine (74-89-5) + benzenesulfonyl chloride (1939-99-7) → N-methyl-1-phenylmethanesulfonamide (19299-41-3)

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/ol048249z

upstream raw materials:

methylamine

benzenesulfonyl chloride

4-hydroxy-2-methyl-5-phenyl-3(2H)-isothiazolone 1,1-dioxide

sodium salt of phenylmethanesulfamide

Downstream raw materials:

N-Methyl-N-((E)-octa-2,7-dienyl)-C-phenyl-methanesulfonamide

benzyl radical

N-methyl-N'-(2,7-octadienyl)-phenylmethanesulfamide

4-hydroxy-2-methyl-5-phenyl-3(2H)-isothiazolone 1,1-dioxide

Refernces

• 1、 Liu, Peng,Tung, Nguyen Thanh,Xu, Xiangchao,Yang, Jiazhi,Li, Feng. "N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]". . p. 2621 - 2631. Retrieved 2021/02/27.
• 2、 Che, Shiying,Zhu, Qiao,Luo, Zhenghong,Lian, Yan,Zhao, Zijian. "Copper-catalyzed oxidative methylation of sulfonamides by dicumyl peroxide". . p. 935 - 942. Retrieved 2021/01/05.