4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1H-isochromene-3-carboxylic acid

Base Information

• Chemical Name: 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1H-isochromene-3-carboxylic acid
• CAS No.: 1451002-44-0
• Molecular Formula: C₂₁H₁₅NO₄
• Molecular Weight: 345.354
• Mol file: 1451002-44-0.mol

Synonyms:4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1H-isochromene-3-carboxylic acid

Chemical Property of 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1H-isochromene-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1H-isochromene-3-carboxylic acid

There total 7 articles about 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1H-isochromene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoic acid (71805-34-0) + Diethyl 2-bromomalonate (685-87-0) → 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1H-isochromene-3-carboxylic acid (1451002-44-0)

Guidance literature:

2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoic acid; Diethyl 2-bromomalonate; With potassium carbonate; In N,N-dimethyl-formamide; acetone; at 20 ℃; for 20h;

With hydrogenchloride; acetic acid; In water; at 120 ℃; for 15h;

DOI:10.3184/174751913X13662146264623

Reference yield:

methyl 2-(1-benzyl-1H-pyrrole-2-carbonyl) benzoate (71739-67-8) → 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1H-isochromene-3-carboxylic acid (1451002-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 1 h / 20 °C

2.1: potassium carbonate / acetone; N,N-dimethyl-formamide / 20 h / 20 °C

2.2: 15 h / 120 °C

With potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; acetone;

DOI:10.3184/174751913X13662146264623

Reference yield:

benzyl bromide (100-39-0) → 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1H-isochromene-3-carboxylic acid (1451002-44-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / tetrahydrofuran

2.1: zinc(II) oxide / neat (no solvent) / 20 °C

3.1: sodium hydroxide / methanol / 1 h / 20 °C

4.1: potassium carbonate / acetone; N,N-dimethyl-formamide / 20 h / 20 °C

4.2: 15 h / 120 °C

With potassium carbonate; potassium hydroxide; zinc(II) oxide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; 2.1: |Friedel-Crafts Acylation;

DOI:10.3184/174751913X13662146264623

upstream raw materials:

2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoic acid

Diethyl 2-bromomalonate

methyl 2-(1-benzyl-1H-pyrrole-2-carbonyl) benzoate

phthalic anhydride

Downstream raw materials:

4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester